Huang Jian, Chen Keqiang, Gong Wanghua, Dunlop Nancy M, Wang Ji Ming
Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
Front Biosci. 2008 May 1;13:3352-63. doi: 10.2741/2930.
Chemoattractant receptors are a group of seven transmembrane, G protein coupled receptors (GPCRs). They were initially identified mainly on leukocytes to mediate cell migration in response to pathogen or host-derived chemotactic factors. During the past decade, chemoattractant GPCRs have been discovered not only to mediate leukocyte chemotaxis thus promoting innate and adaptive host immune responses, but also to play essential roles in development, homeostasis, HIV infection, angiogenesis and wound healing. A growing body of evidence further indicates that chemoattractant GPCRs contribute to tumor growth, invasion, angiogenesis/angiostasis and metastasis. The diverse properties of GPCRs in the progression of malignant tumors have attracted intense interest in their potential as novel anti-tumor pharmacological targets.
化学引诱物受体是一类七次跨膜的G蛋白偶联受体（GPCRs）。它们最初主要在白细胞上被鉴定出来，以介导细胞对病原体或宿主来源的趋化因子作出反应而进行迁移。在过去十年中，人们发现化学引诱物GPCRs不仅介导白细胞趋化作用，从而促进先天性和适应性宿主免疫反应，而且在发育、体内平衡、HIV感染、血管生成和伤口愈合中发挥重要作用。越来越多的证据进一步表明，化学引诱物GPCRs有助于肿瘤生长、侵袭、血管生成/血管抑制和转移。GPCRs在恶性肿瘤进展中的多种特性引起了人们对其作为新型抗肿瘤药理学靶点潜力的浓厚兴趣。
