Wang Gang, Zeng Jie, Ren Rujing, Chen Shengdi
Department of Neurology and Institute of Neuroscience, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
Front Biosci. 2008 May 1;13:3825-38. doi: 10.2741/2971.
A large number studies indicate that potassium (K+) channels play important roles in cellular signaling in both excitable and nonexcitable cells. Moreover, a considerable number of K+ channels within the nervous system appear to mediate diverse cellular signaling, including regulation of neurotransmitter release, neuronal excitability, and cell volume. Recent studies on the K+ channel gene expression in the basal ganglia reveal dysfunctions of various K+ channels (e.g., Kv, K(ATP), Kir2 and SKCa), which may be involved in the pathogenesis of Parkinson's disease (PD). This review aims to provide an overview of our current understanding of the molecular mechanisms involved in K+ channel functions in the basal ganglia, and an insight on how to exploit K+ channels as therapeutic targets in the treatment of PD.
大量研究表明，钾离子（K+）通道在可兴奋细胞和非可兴奋细胞的细胞信号传导中均发挥重要作用。此外，神经系统内相当数量的K+通道似乎介导多种细胞信号传导，包括神经递质释放的调节、神经元兴奋性和细胞体积。近期对基底神经节中K+通道基因表达的研究揭示了各种K+通道（如Kv、K(ATP)、Kir2和SKCa）的功能障碍，这些功能障碍可能与帕金森病（PD）的发病机制有关。本综述旨在概述我们目前对基底神经节中K+通道功能所涉及分子机制的理解，并深入探讨如何将K+通道作为治疗靶点用于PD的治疗。
