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腹足纲软体动物学习与记忆的非突触神经元机制。

Non-synaptic neuronal mechanisms of learning and memory in gastropod molluscs.

作者信息

Benjamin Paul R, Kemenes György, Kemenes Ildikó

机构信息

Sussex Centre for Neuroscience, School of Life Sciences, University of Sussex, Falmer, Brighton, East Sussex, BN1 9QG, UK.

出版信息

Front Biosci. 2008 May 1;13:4051-7. doi: 10.2741/2993.

DOI:10.2741/2993
PMID:18508499
Abstract

Gastropod molluscs provide important model systems for investigating the behavioral and neural basis of associative and non-associative learning. Habituation, sensitization, classical and operant conditioning are studied in motor reflex and central pattern generator circuits. Although synaptic plasticity has long been recognized as playing a key role in molluscan learning circuits, non-synaptic changes resulting in alterations in the excitability of neurons are increasingly recognized as an essential component of the memory trace.

摘要

腹足纲软体动物为研究联想学习和非联想学习的行为及神经基础提供了重要的模型系统。运动反射和中枢模式发生器回路中研究了习惯化、敏感化、经典条件作用和操作性条件作用。尽管长期以来人们一直认为突触可塑性在软体动物学习回路中起关键作用,但导致神经元兴奋性改变的非突触变化越来越被认为是记忆痕迹的重要组成部分。

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