Mushegian Arcady
Stowers Institute for Medical Research, 1000 E 50th St., Kansas City, Missouri 64110, USA.
Front Biosci. 2008 May 1;13:4657-66. doi: 10.2741/3031.
Comparative genomics and modern phylogenetic approaches allow us to infer the gene content of LUCA, the Last Universal Common Ancestor of all known currently living cellular organisms. Most of the estimates produce a putative LUCA with 500-1000 protein-coding genes and biochemically coherent metabolism, if the average rates of gene gains (gene emergence plus horizontal gene transfer) and gene losses per family are allowed to be close to each other. This estimate is not strongly sensitive to the topology of the Tree of Life, but the identity of the genes that are placed in LUCA may depend on the position of the deep branches and the root of the tree.
比较基因组学和现代系统发育方法使我们能够推断出所有已知现存细胞生物的最后共同祖先（LUCA）的基因组成。如果允许每个基因家族的基因获得（基因出现加上水平基因转移）和基因丢失的平均速率接近，大多数估计得出一个假定的LUCA，其具有500 - 1000个蛋白质编码基因和生化上连贯的代谢。这个估计对生命之树的拓扑结构不太敏感，但置于LUCA中的基因的身份可能取决于树的深分支和根的位置。
