Ungvari Zoltan, Buffenstein Rochelle, Austad Steven N, Podlutsky Andrej, Kaley Gabor, Csiszar Anna
Department of Physiology, New York Medical College, Valhalla, New York 10595, USA.
Front Biosci. 2008 May 1;13:5056-70. doi: 10.2741/3064.
Cardiovascular disease is a main cause of morbidity and a leading cause of death of elderly Americans. Studies identifying the pathophysiological mechanisms underlying cardiovascular aging hold promise to develop treatments to delay/prevent coronary artery disease and stroke in the elderly. Evidence supporting the roles of oxidative stress and inflammation in the cardiovascular aging process is presented in detail in this review. Mammalian lifespan ranges hundred-fold and we propose that long-living species may be useful models for successful cardiovascular aging in humans. Comparative studies exploiting the large differences in maximum lifespan potential and cardiovascular aging patterns may be particularly relevant. Comparisons of mechanisms related to oxidative stress, oxidative stress resistance and redox signaling between long-living species and shorter-living ones may elucidate key mechanisms for delaying cardiovascular aging. We discuss the potential use of three long-lived but mouse-sized mammalian species, the naked mole-rat (Heterocephalus glaber), the white-footed mouse (Peromyscus leucopus) and the little brown bat (Myotis lucifugus) to test predictions of the oxidative stress theory of aging and elucidate mechanisms by which cardiovascular aging can be delayed.
心血管疾病是美国老年人发病的主要原因和首要死因。确定心血管衰老潜在病理生理机制的研究有望开发出延缓/预防老年人冠状动脉疾病和中风的治疗方法。本综述详细介绍了支持氧化应激和炎症在心血管衰老过程中作用的证据。哺乳动物的寿命跨度达百倍，我们认为长寿物种可能是人类成功实现心血管衰老的有用模型。利用最大寿命潜力和心血管衰老模式的巨大差异进行的比较研究可能尤为重要。比较长寿物种和短寿物种之间与氧化应激、氧化应激抗性和氧化还原信号相关的机制，可能会阐明延缓心血管衰老的关键机制。我们讨论了三种长寿但体型如小鼠的哺乳动物物种，即裸鼹鼠（Heterocephalus glaber）、白足鼠（Peromyscus leucopus）和小棕蝠（Myotis lucifugus）在测试衰老氧化应激理论预测以及阐明延缓心血管衰老机制方面的潜在用途。
