Morettini Stefano, Podhraski Valerie, Lusser Alexandra
Division of Molecular Biology, Biocenter, Innsbruck Medical University, Fritz-Pregl Strasse 3, A-6020 Innsbruck, Austria.
Front Biosci. 2008 May 1;13:5522-32. doi: 10.2741/3096.
The modification of chromatin structure by various mechanisms has emerged as a key regulatory component of nuclear programs. Cell cycle progression and exit are affected by the integrity of chromatin architecture as well as by regulatory cues that chromatin structure imposes on the expression of cell cycle genes. ATP-dependent chromatin remodeling factors use the energy derived from ATP-hydrolysis to modulate histone-DNA contacts. These molecular machines play important roles in all aspects of chromosome biology and are thus intimately linked to cell cycle control. Regulation of complex activity by various signaling pathways has been a rising theme in recent years. Moreover, some chromatin remodeling factors have been characterized as potent tumor suppressor proteins. Thus, to understand the functions and activities of ATP-utilizing chromatin remodeling factors is an important goal towards their use as potential targets in cancer therapy.
通过各种机制对染色质结构进行修饰已成为细胞核程序的关键调控组成部分。细胞周期进程和退出受染色质结构完整性以及染色质结构对细胞周期基因表达施加的调控信号的影响。依赖ATP的染色质重塑因子利用ATP水解产生的能量来调节组蛋白与DNA的接触。这些分子机器在染色体生物学的各个方面都发挥着重要作用，因此与细胞周期控制密切相关。近年来，各种信号通路对复合物活性的调节一直是一个不断兴起的主题。此外，一些染色质重塑因子已被鉴定为有效的肿瘤抑制蛋白。因此，了解利用ATP的染色质重塑因子的功能和活性是将其用作癌症治疗潜在靶点的一个重要目标。
