Frantz Stefan, Ertl Georg, Bauersachs Johann
Medizinische Klinik und Poliklinik I, Herzkreislauf-Zentrum, Universitätsklinikum Würzburg, Würzburg, Germany.
Front Biosci. 2008 May 1;13:5772-9. doi: 10.2741/3114.
Toll-like receptors (TLRs) have been identified as primary innate immune receptors. They distinguish among different patterns of pathogens and rapidly activate an innate immune response. However, TLRs can also be stimulated by host-derived molecules. TLRs are expressed in the cardiovascular system and could thus be a key link between cardiovascular diseases and the immune system. Increasing evidence suggests that TLR signaling promotes injury in the heart after ischemia, ischemia/reperfusion or hypertrophic stimuli. Herein we review the experimental and clinical evidence for the involvement of TLR and its downstream signaling molecules in cardiac ischemic injury.
Toll样受体（TLRs）已被确定为主要的天然免疫受体。它们能够区分不同模式的病原体，并迅速激活天然免疫反应。然而，TLRs也可被宿主来源的分子激活。TLRs在心血管系统中表达，因此可能是心血管疾病与免疫系统之间的关键联系。越来越多的证据表明，TLR信号传导会促进心脏在缺血、缺血/再灌注或肥大刺激后的损伤。在此，我们综述了TLR及其下游信号分子参与心脏缺血性损伤的实验和临床证据。
