Hartel Paul H, Shackelford Amy L, Hartel James V, Wenger Sharon L
Department of Pathology, West Virginia University, Health Sciences North, Morgantown, West Virginia, USA.
Int J Surg Pathol. 2008 Oct;16(4):419-23. doi: 10.1177/1066896908318935. Epub 2008 May 28.
To elucidate the relationship between del(5q) and the clinical and histological features of small cell neuroendocrine lung carcinoma, 33 tissue samples from patients with this tumor were evaluated. By using fluorescence in situ hybridization, del(5q) was identified in almost 50% of cases (15/33, 45%). Clinically, patients with tumors showing del(5q) were older (mean age = 71 years) with a correspondingly greater pack-year smoking history (mean = 61) than patients with tumors (mean age = 59 years, mean pack-years = 44) without del(5q). Histologically, tumors with del(5q) had a greater frequency of spindle cell morphology (11/14 [79%] vs 6/16 [38%], P < .025) than those without del(5q). This is the first study to find an association between del(5q) and tumor histology in small cell neuroendocrine lung carcinoma.
为阐明5号染色体长臂缺失（del(5q)）与小细胞神经内分泌肺癌的临床及组织学特征之间的关系，对33例该肿瘤患者的组织样本进行了评估。通过荧光原位杂交检测，在近50%的病例（15/33，45%）中发现了del(5q)。临床上，出现del(5q)的肿瘤患者年龄较大（平均年龄 = 71岁），与未出现del(5q)的肿瘤患者（平均年龄 = 59岁）相比，其吸烟史的包年数相应更多（平均 = 61）。组织学上，出现del(5q)的肿瘤具有梭形细胞形态的频率更高（11/14 [79%] 对 6/16 [38%]，P < .025）。这是第一项发现del(5q)与小细胞神经内分泌肺癌肿瘤组织学之间存在关联的研究。
