Ruan Hongyu, Wu Chun-Fang
Department of Biology, University of Iowa, Iowa City, IA 52242, USA.
Proc Natl Acad Sci U S A. 2008 May 27;105(21):7506-10. doi: 10.1073/pnas.0711127105.
Beneficial effects of social interaction on aging have been studied in humans and other species. We found that short-lived Drosophila mutants of the antioxidant enzyme Cu/Zn superoxide dismutase displayed a robust lifespan extension, with improved stress resistance and motor ability, upon cohousing with active flies of longer lifespan or younger age. Genetic, surgical, and environmental manipulations revealed motor and sensory components in behavioral interactions required for the lifespan extension induced by cohousing. Our results provide a definitive case of beneficial social interaction on lifespan and a useful entry point for analyzing the underlying molecular networks and physiological mechanisms.
社交互动对衰老的有益影响已在人类和其他物种中得到研究。我们发现，抗氧化酶铜/锌超氧化物歧化酶的短命果蝇突变体与寿命更长或年龄更小的活跃果蝇共同饲养时，其寿命显著延长，抗应激能力和运动能力也有所提高。基因、手术和环境操作揭示了共同饲养诱导寿命延长所需的行为相互作用中的运动和感觉成分。我们的结果为社交互动对寿命的有益影响提供了一个明确的案例，并为分析潜在的分子网络和生理机制提供了一个有用的切入点。
