• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

针对HIV阴性经典型卡波西肉瘤中的雷帕霉素靶蛋白（mTOR）

Targeting mTOR in HIV-Negative Classic Kaposi's Sarcoma.

作者信息

Merimsky Ofer, Jiveliouk Irina, Sagi-Eisenberg Ronit

机构信息

Unit of Bone and Soft Tissue Oncology, Division of Oncology, Tel-Aviv Sourasky Medical Center, 6 Weitzman Street, Tel-Aviv 64239, Israel.

出版信息

Sarcoma. 2008;2008:825093. doi: 10.1155/2008/825093.

DOI:10.1155/2008/825093
PMID:18509482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2391286/
Abstract

A 66-year old female with HIV-negative classic Kaposi's sarcoma responded to mTOR targeting by rapamycin. The response was well documented by PET-CT. This case provides supporting evidence that the mTOR pathway may be important in the tumorigenesis of KS and that rapamycin may have activity in this disease.

摘要

一名66岁的患有HIV阴性经典型卡波西肉瘤的女性对雷帕霉素靶向mTOR有反应。PET-CT对该反应有充分记录。该病例提供了支持性证据，表明mTOR通路可能在卡波西肉瘤的肿瘤发生中起重要作用，且雷帕霉素可能对这种疾病有活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64de/2391286/0d72ac6d373d/SRCM2008-825093.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64de/2391286/0d72ac6d373d/SRCM2008-825093.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64de/2391286/0d72ac6d373d/SRCM2008-825093.001.jpg

相似文献

1
Targeting mTOR in HIV-Negative Classic Kaposi's Sarcoma.针对HIV阴性经典型卡波西肉瘤中的雷帕霉素靶蛋白（mTOR）
Sarcoma. 2008;2008:825093. doi: 10.1155/2008/825093.
2
Classic Kaposi's sarcoma treated with topical rapamycin.采用局部应用雷帕霉素治疗经典型卡波西肉瘤。
Dermatol Ther. 2015 Jan-Feb;28(1):40-3. doi: 10.1111/dth.12182. Epub 2014 Oct 14.
3
Risk factors for Kaposi's sarcoma in HIV-positive subjects in Uganda.乌干达HIV阳性患者患卡波西肉瘤的风险因素。
AIDS. 1997 Nov;11(13):1619-26. doi: 10.1097/00002030-199713000-00011.
4
Kaposi's sarcoma-associated herpesvirus and Kaposi's sarcoma in Africa. Uganda Kaposi's Sarcoma Study Group.卡波西肉瘤相关疱疹病毒与非洲的卡波西肉瘤。乌干达卡波西肉瘤研究小组。
Arch Intern Med. 1996 Jan 22;156(2):202-4.
5
A role for a new herpes virus (KSHV) in different forms of Kaposi's sarcoma.一种新型疱疹病毒（卡波西肉瘤相关疱疹病毒）在不同类型卡波西肉瘤中的作用。
Nat Med. 1995 Jul;1(7):707-8. doi: 10.1038/nm0795-707.
6
Single Nucleotide Polymorphism Analysis in HIV and Kaposi's Sarcoma Disease by Microarray Technique.采用微阵列技术对HIV与卡波西肉瘤疾病进行单核苷酸多态性分析。
Curr HIV Res. 2020;18(3):154-164. doi: 10.2174/1570162X18666200130100654.
7
Differential expression of p53 and Ki-67 proteins in classic and iatrogenic Kaposi's sarcoma.经典型和医源性卡波西肉瘤中p53和Ki-67蛋白的差异表达
Am J Dermatopathol. 1999 Apr;21(2):138-45. doi: 10.1097/00000372-199904000-00005.
8
Human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) DNA in Kaposi's sarcoma lesions, AIDS Kaposi's sarcoma cell lines, endothelial Kaposi's sarcoma simulators, and the skin of immunosuppressed patients.卡波西肉瘤病变、艾滋病相关卡波西肉瘤细胞系、内皮卡波西肉瘤模拟器以及免疫抑制患者皮肤中的人疱疹病毒8型（卡波西肉瘤相关疱疹病毒）DNA
Am J Pathol. 1996 Jun;148(6):2009-16.
9
Classic Kaposi's sarcoma - complete response to radiation therapy: a case report.经典型卡波西肉瘤——放疗完全缓解：一例报告
J Med Case Rep. 2016 Nov 10;10(1):322. doi: 10.1186/s13256-016-1101-6.
10
[Two HHV8-related illnesses in a HIV-negative patient: Kaposi's sarcoma and multicentric Castleman's disease. Response to treatment with Rituximab and CHOP].一名HIV阴性患者的两种与HHV8相关的疾病：卡波西肉瘤和多中心Castleman病。对利妥昔单抗和CHOP治疗的反应
Actas Dermosifiliogr. 2006 Jul-Aug;97(6):385-90. doi: 10.1016/s0001-7310(06)73425-1.

引用本文的文献

1
MicroRNA expression profiles in Kaposi's sarcoma.卡波西肉瘤中的 microRNA 表达谱。
Pathol Oncol Res. 2014 Jan;20(1):153-9. doi: 10.1007/s12253-013-9678-1. Epub 2013 Sep 13.
2
Mucosal Kaposi sarcoma, a Rare Cancer Network study.黏膜卡波西肉瘤，一项罕见癌症网络研究。
Rare Tumors. 2012 Oct 10;4(4):e49. doi: 10.4081/rt.2012.e49. Epub 2012 Oct 17.
3
Kaposi Sarcoma Pathogenesis: A Triad of Viral Infection, Oncogenesis and Chronic Inflammation.卡波西肉瘤发病机制：病毒感染、肿瘤发生与慢性炎症三联征

本文引用的文献

1
Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma.卡波西肉瘤疱疹病毒G蛋白偶联受体激活Akt/TSC/mTOR：对卡波西肉瘤分子肿瘤发生机制及治疗的新见解
Cell Cycle. 2007 Feb 15;6(4):438-43. doi: 10.4161/cc.6.4.3843. Epub 2007 Feb 12.
2
F-18 fluorodeoxyglucose PET/CT as an imaging tool for staging and restaging cutaneous angiosarcoma of the scalp.F-18氟脱氧葡萄糖PET/CT作为头皮皮肤血管肉瘤分期及再分期的影像学检查工具
Clin Nucl Med. 2006 Sep;31(9):534-7. doi: 10.1097/01.rlu.0000233073.12599.0a.
3
Complete regression of visceral Kaposi's sarcoma after conversion to sirolimus.
Transl Biomed. 2010;1(2).
4
Phosphatase and tensin homolog on chromosome 10 is phosphorylated in primary effusion lymphoma and Kaposi's sarcoma.第 10 号染色体上的磷酸酶和张力蛋白同源物在原发性渗出性淋巴瘤和卡波西肉瘤中发生磷酸化。
Am J Pathol. 2011 Oct;179(4):2108-19. doi: 10.1016/j.ajpath.2011.06.017. Epub 2011 Aug 3.
5
Rapamycin blocks production of KSHV/HHV8: insights into the anti-tumor activity of an immunosuppressant drug.雷帕霉素阻断 KSHV/HHV8 的产生：免疫抑制剂药物抗肿瘤活性的新见解。
PLoS One. 2011 Jan 14;6(1):e14535. doi: 10.1371/journal.pone.0014535.
6
Target therapy in gastrointestinal tract sarcoma: What is new?胃肠道间质瘤的靶向治疗：有哪些新进展？
World J Gastrointest Oncol. 2010 Jan 15;2(1):1-4. doi: 10.4251/wjgo.v2.i1.1.
7
The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor: Lessons on dysregulated angiogenesis from a viral oncogene.卡波西肉瘤相关疱疹病毒 G 蛋白偶联受体：病毒癌基因对失调的血管生成的启示。
J Cell Biochem. 2010 May;110(1):1-9. doi: 10.1002/jcb.22524.
8
Dual inhibition of PI3Kalpha and mTOR as an alternative treatment for Kaposi's sarcoma.双重抑制PI3Kα和mTOR作为卡波西肉瘤的替代治疗方法。
Cancer Res. 2008 Oct 15;68(20):8361-8. doi: 10.1158/0008-5472.CAN-08-0878.
转换为西罗莫司治疗后内脏卡波西肉瘤完全消退。
Exp Clin Transplant. 2005 Dec;3(2):366-9.
4
Sirolimus does double duty after organ transplantation.
Lancet Oncol. 2005 May;6(5):261. doi: 10.1016/s1470-2045(05)70146-7.
5
PI3-kinase and TOR: PIKTORing cell growth.磷脂酰肌醇-3激酶与雷帕霉素靶蛋白：调控细胞生长的信号通路环
Semin Cell Dev Biol. 2004 Apr;15(2):147-59. doi: 10.1016/j.semcdb.2003.12.023.
6
Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor.Akt在卡波西肉瘤疱疹病毒编码的G蛋白偶联受体诱导的肉瘤发生中起核心作用。
Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4821-6. doi: 10.1073/pnas.0400835101. Epub 2004 Mar 26.
7
mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E.mTOR通过其细胞生长效应因子S6K1和4E-BP1/真核翻译起始因子4E来控制细胞周期进程。
Mol Cell Biol. 2004 Jan;24(1):200-16. doi: 10.1128/MCB.24.1.200-216.2004.
8
Novel regulatory mechanisms of mTOR signaling.mTOR信号通路的新型调控机制
Curr Top Microbiol Immunol. 2004;279:245-57. doi: 10.1007/978-3-642-18930-2_14.
9
Rapamycins: mechanism of action and cellular resistance.雷帕霉素：作用机制与细胞抗性
Cancer Biol Ther. 2003 May-Jun;2(3):222-32. doi: 10.4161/cbt.2.3.360.
10
Mammalian target of rapamycin: a new molecular target for breast cancer.雷帕霉素的哺乳动物靶点：乳腺癌的一个新分子靶点。
Clin Breast Cancer. 2003 Jun;4(2):126-37. doi: 10.3816/cbc.2003.n.018.