乳腺癌中利用扩散加权磁共振成像测定癌组织细胞密度与表观扩散系数值之间的关系
Relation between cancer cellularity and apparent diffusion coefficient values using diffusion-weighted magnetic resonance imaging in breast cancer.
作者信息
Yoshikawa Miho I, Ohsumi Shozo, Sugata Shigenori, Kataoka Masaaki, Takashima Shigemitsu, Mochizuki Teruhito, Ikura Hirohiko, Imai Yutaka
机构信息
Department of Radiology, Tokai University School of Medicine, Tokai University Hachioji Hospital, 1838 Ishikawa, Hachioji, Tokyo 192-0032, Japan.
出版信息
Radiat Med. 2008 May;26(4):222-6. doi: 10.1007/s11604-007-0218-3. Epub 2008 May 29.
PURPOSE
The purpose of this study was to examine the relation between cancer cellularity and the apparent diffusion coefficient (ADC) value using diffusion-weighted magnetic resonance imaging in breast cancer.
MATERIALS AND METHODS
The subjects were 27 women who had undergone operation for breast cancer. There were 27 breast cancer lesions, 24 of which were invasive ductal carcinoma (IDC) and 3 of which were noninvasive ductal carcinoma (NIDC).
RESULTS
The mean ADC values of IDC, NIDC, and normal breasts were 1.07 +/- 0.19 .10(-3), 1.42 +/- 0.17 .10(-3), and 1.96 +/- 0.21 .10(-3) mm(2)/s, respectively. The mean ADC values of IDC and NIDC were significantly different from that of normal breasts (P < 0.001 each). The mean ADC values were also significantly different between IDC and NIDC (P < 0.001). There was no correlation between the ADC value and cancer cellularity.
CONCLUSION
The mean ADC values for breast cancer were significantly different from that of normal breasts. The mean ADC value for breast cancer did not significantly correlate with cancer cellularity but did correlate with histological types.
目的
本研究旨在利用扩散加权磁共振成像检查乳腺癌中癌细胞密度与表观扩散系数（ADC）值之间的关系。
材料与方法
研究对象为27例接受过乳腺癌手术的女性。共有27个乳腺癌病灶，其中24个为浸润性导管癌（IDC），3个为非浸润性导管癌（NIDC）。
结果
IDC、NIDC和正常乳腺的平均ADC值分别为1.07±0.19×10⁻³、1.42±0.17×10⁻³和1.96±0.21×10⁻³mm²/s。IDC和NIDC的平均ADC值与正常乳腺的平均ADC值均有显著差异（均为P<0.001）。IDC和NIDC之间的平均ADC值也有显著差异（P<0.001）。ADC值与癌细胞密度之间无相关性。
结论
乳腺癌的平均ADC值与正常乳腺的平均ADC值有显著差异。乳腺癌的平均ADC值与癌细胞密度无显著相关性，但与组织学类型相关。
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