Sárosi Andrea, Balogh Gabriella, Székely Anna, Sasvári Mária, Faludi Gábor
Semmelweis Egyetem Kútvölgyi Klinikai Tömb, Klinikai és Kutatási Mentálhigiénés Osztály, Budapest.
Neuropsychopharmacol Hung. 2007 Dec;9(4):183-8.
Neuropsychological deficits have been reported in patients with major depressive disorder in a lot of lectures. The aim of the present study was to measure the neurocognitive functions of major depressive patients and healthy controls, and identify some vulnerability marker of the disease. Seventy-one patients with major depressive disorder were compared to thirty healthy control subjects on tasks from Trail Making Test, Stroop Test, Rey Verbal Auditory Learning Test and Rey-Osterreich Figure Test. Patients with depression relative to controls were significantly impaired on tasks of attention, executive function, memory and psychomotor speed, but not in visuo-spatial function. These findings suggest deficits in cognitive function as, attention, visual and verbal memory and learning, as vulnerability marker for major depressive disorder. The second important finding, the better result of the visual perception and short memory in depressed patient, was caused by intact hippocampal function. The functional importance of this result is the connection of the neuronal network and signs of depression.
在许多讲座中都报道过，重度抑郁症患者存在神经心理缺陷。本研究的目的是测量重度抑郁症患者和健康对照者的神经认知功能，并确定该疾病的一些易损标志物。将71名重度抑郁症患者与30名健康对照者进行比较，进行连线测验、斯特鲁普测验、雷伊听觉词语学习测验和雷-奥斯特里赫图形测验。与对照组相比，抑郁症患者在注意力、执行功能、记忆和心理运动速度任务上有显著损害，但视觉空间功能未受影响。这些发现表明，认知功能如注意力、视觉和言语记忆及学习方面的缺陷，可作为重度抑郁症的易损标志物。第二个重要发现是，抑郁症患者视觉感知和短时记忆的较好结果是由海马功能完好所致。这一结果的功能重要性在于神经网络与抑郁症状之间的联系。
