肝细胞癌患者对乙酰氨基酚的氧化代谢增加。

Increased oxidative metabolism of paracetamol in patients with hepatocellular carcinoma.

作者信息

Leung N W, Critchley J A

机构信息

Department of Clinical Pharmacology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories.

出版信息

Cancer Lett. 1991 Apr;57(1):45-8. doi: 10.1016/0304-3835(91)90061-l.

DOI:10.1016/0304-3835(91)90061-l

PMID:1851052

Abstract

Oxidative metabolism (OM) of paracetamol was studied in 19 patients with hepatocellular carcinoma (HCC), 39 with chronic hepatitis B virus infection (CHBV) and 26 healthy controls. Paracetamol (1.5 g) was given and the subsequent 24 h urine collection assayed for paracetamol and its metabolites by HPLC. HCC patients showed greatly increased OM, as reflected by the combined fractional recoveries of mercapturic acid and cysteine conjugates (22%), in comparison with controls (7%) and CHBV patients (10%). As the cytochrome P-450 dependent OM of xenobiotics has been implicated in carcinogenesis, it is interesting that two CHBV patients also had increased OM.

摘要

对19例肝细胞癌（HCC）患者、39例慢性乙型肝炎病毒感染（CHBV）患者和26名健康对照者进行了对乙酰氨基酚的氧化代谢（OM）研究。给予对乙酰氨基酚（1.5克），并通过高效液相色谱法（HPLC）对随后24小时收集的尿液检测对乙酰氨基酚及其代谢产物。与对照组（7%）和CHBV患者（10%）相比，HCC患者的OM显著增加，这通过硫醚氨酸和半胱氨酸结合物的联合分数回收率（22%）得以体现。由于细胞色素P-450依赖性外源性物质的OM与致癌作用有关，有趣的是，两名CHBV患者的OM也有所增加。