Kim Hyun-Seung, Yang Yunzhi, Koh Jeong-Tae, Lee Kyung-Ku, Lee Doh-Jae, Lee Kwang-Min, Park Sang-Won
Department of Prosthodontics, School of Dentistry, Chonnam National University, Gwangju, Korea.
J Biomed Mater Res B Appl Biomater. 2009 Feb;88(2):427-35. doi: 10.1002/jbm.b.31124.
The purpose of this study was to fabricate and characterize nanotubular structure on machined titanium (MA) and resorbable blast media (RBM) treated titanium by anodizing. The anodized MA and RBM were characterized with scanning electron microscopy, transmission electron microscopy, X-ray diffraction, energy disperse spectra, X-ray photoelectron spectra, and nano-indentation and scratch test. Highly ordered nanotubular layers of individually 100 nm in diameter and 500 nm in length approximately were formed regardless of the substrates. The nanotubular layers consisted mainly of amorphous TiO(2) with trace fluorine. The nanotubular surfaces on both the substrates significantly reduced water contact angles and elastic modulus compared with those prior to anodizing. The anodizing treatment significantly increased the surface roughness of the smooth MA, but significantly decreased the surface roughness of the roughened RBM. The critical delamination forces of the nanotubular layer were not obtained due to the limitation of surface roughness. The anodized RBM consisted of a nano-micro porous graded structure, or a nanotubular amorphous fluoride containing TiO(2) layer on top of micro-roughened titanium surface, which is expected to significantly improve the surface area that can be used to deliver drugs and growth factors and alleviate the interfacial elastic modulus mismatch as to enhance osseointegration when compared with conventional dental and orthopedic implant devices with smooth or acid etched surface.
本研究的目的是通过阳极氧化在加工钛（MA）和可吸收喷砂介质（RBM）处理的钛上制备并表征纳米管结构。对阳极氧化后的MA和RBM进行扫描电子显微镜、透射电子显微镜、X射线衍射、能谱、X射线光电子能谱以及纳米压痕和划痕测试。无论基底如何，均形成了直径约为100 nm、长度约为500 nm的高度有序纳米管层。纳米管层主要由含微量氟的非晶TiO₂组成。与阳极氧化前相比，两种基底上的纳米管表面均显著降低了水接触角和弹性模量。阳极氧化处理显著增加了光滑MA的表面粗糙度，但显著降低了粗糙RBM的表面粗糙度。由于表面粗糙度的限制，未获得纳米管层的临界分层力。阳极氧化后的RBM由纳米-微孔梯度结构组成，即在微粗糙钛表面上有一层含TiO₂的纳米管非晶氟化物层，与具有光滑或酸蚀表面的传统牙科和骨科植入装置相比，预计该结构可显著增加可用于递送药物和生长因子的表面积，并减轻界面弹性模量失配，从而增强骨整合。
