Department of Periodontology, School of Dentistry, Kyungpook National University, 188-I, Samduk 2Ga, Jung-Gu Daegu 700-412, Korea.
Clin Oral Implants Res. 2012 Mar;23(3):294-300. doi: 10.1111/j.1600-0501.2010.02144.x. Epub 2011 Mar 24.
Recent studies have suggested that magnesium (Mg) ions exert a beneficial effect on implant osseointegration. This study assessed the osseointegration of nanoporous titanium (Ti) surface incorporating the Mg produced by hydrothermal treatment in rabbit cancellous bone to determine whether this surface would further enhance bone healing of moderately rough-surfaced implants in cancellous bone, and compared the result with commercially available micro-arc oxidized Mg-incorporated implants.
The Mg-incorporated Ti surfaces (RBM/Mg) were obtained by hydrothermal treatment using an alkaline Mg-containing solution on grit-blasted moderately rough (RBM) implants. Untreated RBM and recently introduced Mg-incorporated microporous Ti implants produced by micro-arc oxidation (M) were used controls in this study. The surface characteristics were evaluated by scanning electron microscopy, X-ray photoelectron spectroscopy and optical profilometry. Twenty-four threaded implants with a length of 10 mm (eight RBM implants, eight RBM/Mg implants and eight M implants) were placed in the femoral condyles of 12 New Zealand White rabbits. Histomorphometric analysis was performed 4 weeks after implantation.
Hydrothermally treated and untreated grit-blasted implants displayed almost identical surface morphologies and R(a) values at the micron-scale. The RBM/Mg implants exhibited morphological differences compared with the RBM implants at the nano-scale, which displayed nanoporous surface structures. The Mg-incorporated implants (RBM/Mg and M) exhibited more continuous bone apposition and a higher degree of bone-to-implant contact (BIC) than the untreated RBM implants in rabbit cancellous bone. The RBM/Mg implants displayed significantly greater BIC% than untreated RBM implants, both in terms of the all threads region and the total lateral length of implants (P<0.05), but no statistical differences were found between the RBM/Mg and M implants except BIC% values in total lateral length.
These results indicate that a nanoporous Mg-incorporated surface may be effective in enhancing the osseointegration of moderately rough grit-blasted implants by increasing the degree of bone-implant contact in areas of cancellous bone.
最近的研究表明，镁（Mg）离子对种植体骨整合具有有益作用。本研究评估了通过水热处理在兔松质骨中形成的纳米多孔钛（Ti）表面的骨整合情况，以确定这种表面是否会进一步增强中度粗糙表面种植体在松质骨中的骨愈合，并将结果与市售的微弧氧化 Mg 掺入种植体进行比较。
通过在喷丸中度粗糙（RBM）植入物上使用碱性含 Mg 溶液进行水热处理获得 Mg 掺入 Ti 表面（RBM/Mg）。在这项研究中，未处理的 RBM 和最近引入的通过微弧氧化（M）产生的 Mg 掺入微孔 Ti 植入物被用作对照。通过扫描电子显微镜、X 射线光电子能谱和光学轮廓仪评估表面特性。将 24 个长度为 10mm 的螺纹植入物（8 个 RBM 植入物、8 个 RBM/Mg 植入物和 8 个 M 植入物）放置在 12 只新西兰白兔的股骨髁中。植入后 4 周进行组织形态计量学分析。
水热处理和未处理的喷丸植入物在微米尺度上显示出几乎相同的表面形态和 R(a) 值。与 RBM 植入物相比，RBM/Mg 植入物在纳米尺度上显示出不同的形态，表现出纳米多孔表面结构。与未处理的 RBM 植入物相比，Mg 掺入的植入物（RBM/Mg 和 M）在兔松质骨中表现出更连续的骨附着和更高的骨与植入物接触（BIC）程度。RBM/Mg 植入物的 BIC%显著高于未处理的 RBM 植入物，无论是在所有螺纹区域还是在植入物的总横向长度上（P<0.05），但 RBM/Mg 和 M 植入物之间除了总横向长度上的 BIC%值外，没有发现统计学差异。
这些结果表明，纳米多孔 Mg 掺入表面可能通过增加松质骨区域骨与植入物的接触程度，有效增强中度粗糙喷丸植入物的骨整合。
