使用三聚氯氰和三氯化铝从羧酸进行温和、高效的傅克酰基化反应。
Mild, efficient Friedel-Crafts acylations from carboxylic acids using cyanuric chloride and AlCl3.
作者信息
Kangani Cyrous O, Day Billy W
机构信息
Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.
出版信息
Org Lett. 2008 Jul 3;10(13):2645-8. doi: 10.1021/ol800752v. Epub 2008 May 31.
PMID:18512929
Abstract
A mild method for Friedel-Crafts acylation with aromatic and aliphatic carboxylic acids using cyanuric chloride, pyridine, and AlCl(3) was developed. Both inter- and intramolecular acylations were achieved at room temperature in high yield and in very short reaction times.
摘要
开发了一种使用三聚氯氰、吡啶和AlCl₃，以温和方式用芳香族和脂肪族羧酸进行傅克酰基化反应的方法。分子间和分子内酰化反应均在室温下以高产率和极短的反应时间实现。
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