Wang Lei, Murai Yuta, Yoshida Takuma, Okamoto Masashi, Tachrim Zetryana Puteri, Hashidoko Yasuyuki, Hashimoto Makoto
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, Kita-ku, Sapporo 060-8589, Japan.
Faculty of Advanced Life Science, Frontier Research Center for Post-Genome Science and Technology, Hokkaido University, Kita 21, Nishi 11, Kita-ku, Sapporo 001-0021, Japan.
Molecules. 2014 May 16;19(5):6349-67. doi: 10.3390/molecules19056349.
Aryl-keto-containing α-amino acids are of great importance in organic chemistry and biochemistry. They are valuable intermediates for the construction of hydroxyl α-amino acids, nonproteinogenic α-amino acids, as well as other biofunctional components. Friedel-Crafts acylation is an effective method to prepare aryl-keto derivatives. In this review, we summarize the preparation of aryl-keto containing α-amino acids by Friedel-Crafts acylation using acidic α-amino acids as acyl-donors and Lewis acids or Brönsted acids as catalysts.
含芳基酮的α-氨基酸在有机化学和生物化学中具有重要意义。它们是构建羟基α-氨基酸、非蛋白质ogenicα-氨基酸以及其他生物功能成分的有价值中间体。傅克酰基化是制备芳基酮衍生物的有效方法。在本综述中，我们总结了以酸性α-氨基酸为酰基供体，以路易斯酸或布朗斯特酸为催化剂，通过傅克酰基化反应制备含芳基酮的α-氨基酸的方法。
