Wu Chien-Chang, Yen Ming-Hong, Yang Shyh-Chyun, Lin Chun-Nan
School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
J Nat Prod. 2008 Jun;71(6):1027-31. doi: 10.1021/np8001145. Epub 2008 May 31.
A new phloroglucinol, hyperielliptone HA (1/1a), a new spirophloroglucinol possessing an unprecedented skeleton, hyperielliptone HB (2/2a), and two new xanthonolignoids, hyperielliptones HC (3) and HD (4), were isolated from the heartwood of Hypericum geminiflorum. Compounds 1/1a and 2/2a were obtained as tautomeric pairs. The structures and relative configurations of these compounds were elucidated by spectroscopic methods. In biological testing, compound 2/ 2a revealed significant inhibition of oxidative DNA damage and an inhibitory effect on xanthine oxidase.
从双花金丝桃的心材中分离出一种新的间苯三酚——金丝桃椭圆酮HA（1/1a），一种具有前所未有的骨架的新的螺环间苯三酚——金丝桃椭圆酮HB（2/2a），以及两种新的呫吨木脂素——金丝桃椭圆酮HC（3）和HD（4）。化合物1/1a和2/2a以互变异构体对的形式获得。这些化合物的结构和相对构型通过光谱方法得以阐明。在生物测试中，化合物2/2a显示出对氧化性DNA损伤的显著抑制作用以及对黄嘌呤氧化酶的抑制作用。
