Li Jiong, Vestergaard Mogens, Obel Carsten, Precht Dorthe Hansen, Christensen Jakob, Lu Michael, Olsen Jørn
Danish Epidemiology Science Centre, Department of Epidemiology, Institute of Public Health, University of Aarhus, Aarhus C, Denmark.
Epilepsy Res. 2008 Sep;81(1):52-7. doi: 10.1016/j.eplepsyres.2008.04.014. Epub 2008 Jun 2.
To examine whether prenatal exposure to maternal bereavement is associated with an increased risk of epilepsy in the first decades of life.
We conducted a population-based cohort study of children (N=1,553,966) born in Denmark from 1978 to 2004. A total of 39,867 children born to women who lost a close relative while pregnant or within 1 year before the pregnancy were included in the exposed cohort. The main outcome of interest was hospitalization due to epilepsy (ICD 8 codes 345.00-345.99, ICD 10 codes G40.0-G41.9). We used log-linear Poisson models to estimate incidence rate ratios (IRRs).
The exposed children had a risk of epilepsy similar to that of unexposed children (IRR 1.06, 95% CI 0.96-1.18). The IRRs were 1.08 (95% CI 0.89-1.31) for the children of women who lost a child, and 1.02 (95% CI 0.91-1.15) for the children of women who lost a partner, parent or sibling. The IRRs did not differ according to the timing of exposure or the causes of death (unexpected causes and other causes).
Our data do not suggest any strong association between prenatal stress and epilepsy in the first decades of life.
探讨孕期母亲经历丧亲之痛是否会增加子女在生命最初几十年患癫痫的风险。
我们对1978年至2004年在丹麦出生的儿童（N = 1,553,966）进行了一项基于人群的队列研究。暴露队列纳入了39,867名母亲在孕期或怀孕前1年内失去近亲的儿童。主要关注的结局是因癫痫住院（国际疾病分类第8版编码345.00 - 345.99，国际疾病分类第10版编码G40.0 - G41.9）。我们使用对数线性泊松模型来估计发病率比（IRR）。
暴露组儿童患癫痫的风险与未暴露组儿童相似（IRR 1.06，95%置信区间0.96 - 1.18）。母亲失去孩子的儿童的IRR为1.08（95%置信区间0.89 - 1.31），母亲失去伴侣、父母或兄弟姐妹的儿童的IRR为1.02（95%置信区间0.91 - 1.15）。IRR在暴露时间或死亡原因（意外原因和其他原因）方面没有差异。
我们的数据并未表明生命最初几十年的产前应激与癫痫之间存在任何强关联。
