Ingstrup Katja Glejsted, Schou Andersen Camilla, Ajslev Teresa Adeltoft, Pedersen Pernille, Sørensen Thorkild I A, Nohr Ellen A
Section for Epidemiology, Department of Public Health, Aarhus University, Bartholins Allé 2, 8000 Aarhus C, Denmark.
J Obes. 2012;2012:462845. doi: 10.1155/2012/462845. Epub 2012 May 22.
Background. Maternal distress during pregnancy increases the intrauterine level of glucocorticoids, which may have long-term health consequences for the child. Objective. To examine if distress as a combined measure of anxiety, depression, and stress of the mother during pregnancy was associated with offspring childhood overweight at age 7. Methods. We performed a cohort study using prospective data from 37,764 women and child dyads from the Danish National Birth Cohort (1996-2002). At a telephone interview at approximately 30 weeks gestation, the women reported whether they felt anxious, depressed, or stressed. The 95 percentile for body mass index in an international reference defined childhood overweight at any given age. Logistic regression was used for the analyses. Results. The prevalence of overweight children at 7 years of age was 9.9%. Prenatal exposure to maternal distress during pregnancy was not associated with childhood overweight at 7 years of age (adjusted OR 1.06 (95% CI 0.96; 1.18)). In analyses stratified on sex, a small tendency of overweight was seen in boys (OR 1.15 (0.99; 1.33)), but not in girls (OR 0.98 (0.85; 1.13)). Conclusions. Maternal distress during pregnancy appeared to have limited, if any, influence on the risk of overweight in offspring at 7 years of age.
背景。孕期母亲的情绪困扰会增加子宫内糖皮质激素水平，这可能会对孩子产生长期的健康影响。目的。研究孕期母亲焦虑、抑郁和压力综合衡量的情绪困扰是否与孩子7岁时的儿童期超重有关。方法。我们利用丹麦国家出生队列（1996 - 2002年）中37764对母婴的前瞻性数据进行了一项队列研究。在妊娠约30周时的电话访谈中，母亲们报告了她们是否感到焦虑、抑郁或有压力。国际参考标准中体重指数的第95百分位数定义了任何给定年龄的儿童超重情况。采用逻辑回归进行分析。结果。7岁儿童超重的患病率为9.9%。孕期母亲情绪困扰与7岁儿童超重无关（调整后的比值比为1.06（95%置信区间为0.96；1.18））。在按性别分层的分析中，男孩有轻微的超重倾向（比值比为1.15（0.99；1.33）），但女孩没有（比值比为0.98（0.85；1.13））。结论。孕期母亲的情绪困扰对7岁后代超重风险的影响似乎有限（如果有影响的话）。
