Jin bBong Joon, Lee Yong Seop, Jeong Seung Won, Jeong Jin Hyeok, Lee Seung Hwan, Tae Kyung
Department of Otolaryngology-Head and Neck Surgery, School of Medicne, Hangyang University, Seoul, Korea.
Laryngoscope. 2008 May;118(5):938-41. doi: 10.1097/MLG.0b013e3181651c3a.
To evaluate the usefulness of acoustic parameters as an indicator of laryngopharyngeal reflux (LPR) treatment efficacy.
A prospective case series analysis.
From January to September 2005, we prospectively analyzed 40 patients who were diagnosed with laryngopharyngeal reflux by 24-hour ambulatory double-probe pH monitoring. Laryngopharyngeal reflux patients were treated medically and voice analysis was conducted three times: before treatment, 1 to 2 months after treatment, and 3 to 4 months after treatment. Jitter, shimmer, and harmonic-to-noise ratio (HNR) were analyzed as the acoustic parameters. Pre- and posttreatment reflux symptom index and reflux finding score were documented.
Jitter, shimmer, and HNR had improved significantly at 1 to 2 months after treatment and were maintained at 3 to 4 months after treatment. Jitter was significantly correlated with reflux symptom index.
Acoustic parameters can be used as indicators of treatment efficacy for laryngopharyngeal reflux disease.
评估声学参数作为喉咽反流（LPR）治疗效果指标的实用性。
前瞻性病例系列分析。
2005年1月至9月，我们前瞻性分析了40例经24小时动态双探头pH监测诊断为喉咽反流的患者。对喉咽反流患者进行药物治疗，并在治疗前、治疗后1至2个月以及治疗后3至4个月进行三次嗓音分析。分析抖动、闪烁和信噪比（HNR）作为声学参数。记录治疗前后的反流症状指数和反流发现评分。
治疗后1至2个月，抖动、闪烁和HNR显著改善，并在治疗后3至4个月维持改善。抖动与反流症状指数显著相关。
声学参数可作为喉咽反流疾病治疗效果的指标。
