Koufman J A, Amin M R, Panetti M
Center for Voice Disorders, Department of Otolaryngology, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1034, USA.
Otolaryngol Head Neck Surg. 2000 Oct;123(4):385-8. doi: 10.1067/mhn.2000.109935.
The goal was to estimate the prevalence of laryngopharyngeal reflux (LPR) in patients with laryngeal and voice disorders.
This was a prospective study of 113 unselected, new patients with laryngeal and voice disorders. Patients completed an extensive medical history form including a reflux symptom profile. A comprehensive otolaryngologic examination was performed with photographic transnasal fiberoptic laryngoscopy. Patients with both symptoms and findings of LPR (78/133, 69%) underwent ambulatory 24-hour double-probe pH monitoring.
Seventy-three percent (57/78) of patients undergoing pH testing had abnormal studies. Thus 50% (57/113) of the entire the study population had pH-documented reflux. Of the diagnostic sub-groups studied, the highest incidence of reflux was found in patients with vocal cord neoplastic lesions (88%) and patients with muscle tension dysphonias (70%). LPR was infrequently found in patients with neuromuscular disorders.
LPR occurs in at least 50% of all patients at our center with laryngeal and voice disorders at presentation.
本研究旨在评估喉咽反流（LPR）在喉及嗓音疾病患者中的患病率。
这是一项针对113例未经筛选的新发喉及嗓音疾病患者的前瞻性研究。患者填写了一份详尽的病史表格，其中包括反流症状清单。通过经鼻纤维喉镜摄影进行了全面的耳鼻喉科检查。有LPR症状和体征的患者（78/133，69%）接受了24小时动态双探头pH监测。
接受pH测试的患者中有73%（57/78）检查结果异常。因此，整个研究人群中有50%（57/113）的患者有pH记录的反流情况。在所研究的诊断亚组中，反流发生率最高的是声带肿瘤性病变患者（88%）和肌肉紧张性发音障碍患者（70%）。神经肌肉疾病患者中很少发现LPR。
在我们中心，至少50%的初诊喉及嗓音疾病患者存在LPR。
