Myers J E, Macun I
Department of Community Health, Medical School, University of Cape Town, Observatory, South Africa.
Am J Ind Med. 1991;19(4):487-93. doi: 10.1002/ajim.4700190406.
Acrylamide monomer concentrations and peripheral neurotoxicity were investigated in workers at a factory producing polymer. Monomer levels ranged from 0.07 to 2.5 times the recommended exposure limit of the U.S. National Institute for Occupational Safety and Health (1988). Those workers with exposure exceeding the limit had increased prevalences of acrylamide-related abnormalities. Logistic regression showed dose-response relationships with exposure for symptoms, abnormal sensation, decreased motor strength, abnormal gait or rombergism, and skin abnormalities. The overall prevalence of acrylamide-related abnormality was 32% in the total work force and 67% among those exceeding the limit compared with 14% in those exposed below the limit. Environmental exposure determinations and conventional clinical approaches are relatively insensitive measures. Associations might have been stronger if a biological exposure measure had existed and if quantitative neurometric techniques had been applied. Electrophysiological methods are not readily available in many settings; the use of the Vibration II for quantitative field testing holds promise.
对一家生产聚合物的工厂的工人进行了丙烯酰胺单体浓度和周围神经毒性的调查。单体水平为美国国家职业安全与健康研究所（1988年）推荐接触限值的0.07至2.5倍。那些接触量超过限值的工人中，与丙烯酰胺相关的异常情况患病率增加。逻辑回归显示，症状、感觉异常、运动力量下降、步态异常或闭目难立征以及皮肤异常与接触存在剂量反应关系。在全体劳动力中，与丙烯酰胺相关异常的总体患病率为32%，在超过限值的工人中为67%，而在接触低于限值的工人中为14%。环境接触测定和传统临床方法是相对不敏感的措施。如果存在生物接触测量方法并且应用了定量神经测量技术，关联可能会更强。电生理方法在许多情况下不易获得；使用Vibration II进行定量现场测试有前景。
