Deng H, He F, Zhang S, Calleman C J, Costa L G
Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing.
Int Arch Occup Environ Health. 1993;65(1):53-6. doi: 10.1007/BF00586059.
The early detection of impaired vibration sensation is necessary in order to monitor the adverse effects in workers occupationally exposed to neurotoxic chemicals such as acrylamide. The conventional neurological examination which assesses vibration sensation by utilizing a tuning fork is relatively insensitive for this purpose. In the present study, the Vibration II, a new device for the quantitative measurement of vibration thresholds, was used in 105 healthy Chinese adults. A new testing procedure combining the "two-alternative forced-choice procedure" and the "yes-or-no method-of-limits procedure" showed good reliability and was less time consuming. The results indicate that significant differences in the vibration threshold of index fingers and great toes were found neither between males and females, nor between the left and the right side. However, there was an age-dependent increase in vibration threshold in nonexposed healthy subjects. The vibration thresholds of 41 workers exposed to acrylamide detected by the Vibration II were significantly higher than those of the healthy adults in the same age group. The quantitative measurement of vibration threshold seems to be potentially useful for screening peripheral nerve dysfunction in field studies.
为监测职业性接触神经毒性化学物质（如丙烯酰胺）的工人的不良反应，早期发现振动觉受损很有必要。利用音叉评估振动觉的传统神经学检查在此方面相对不敏感。在本研究中，一种用于定量测量振动阈值的新设备——振动II型，被应用于105名健康中国成年人。一种将“二项必选迫选法”和“是或否极限法”相结合的新测试程序显示出良好的可靠性且耗时较少。结果表明，食指和大脚趾的振动阈值在男性和女性之间以及左右两侧之间均未发现显著差异。然而，在未接触的健康受试者中，振动阈值随年龄增长而升高。用振动II型检测的41名接触丙烯酰胺的工人的振动阈值显著高于同年龄组的健康成年人。振动阈值的定量测量似乎在现场研究中对筛查周围神经功能障碍有潜在用途。
