College of Clinical Medicine, Jining Medical University, Jining, 272013, Shandong Province, China.
Department of Gastroenterology, Jining No. 1 People's Hospital, Jining, 272000, Shandong Province, China.
Biol Trace Elem Res. 2024 Nov;202(11):4923-4931. doi: 10.1007/s12011-024-04074-y. Epub 2024 Feb 16.
One set of chronic gastrointestinal disorders called inflammatory bowel disease (IBD) is defined by persistent, non-specific inflammation. Abdominal pain, hematochezia, diarrhea, and other symptoms are among its clinical signs. Currently, managing and treating IBD remains a significant challenge. Patients with IBD frequently have deficits in trace elements. Selenium (Se) is one of the necessary trace elements for normal organismal function. It has several regulatory effects, including anti-oxidation, anti-inflammatory, and defensive properties, via inducing the synthesis of selenoproteins. Patients with IBD have been shown to have lower Se levels in epidemiologic research studies. Several experimental models of IBD suggest that Se or selenoproteins play a key role in microinflammation. We discuss the relationship between Se and IBD in this review, with an emphasis on a summary of potential mechanisms of action and applications of Se in IBD.
一组称为炎症性肠病（IBD）的慢性胃肠道疾病是由持续性、非特异性炎症定义的。其临床特征包括腹痛、血便、腹泻和其他症状。目前，管理和治疗 IBD 仍然是一个重大挑战。IBD 患者经常存在微量元素缺乏。硒（Se）是正常生物体功能所必需的微量元素之一。它通过诱导硒蛋白的合成，具有多种调节作用，包括抗氧化、抗炎和防御特性。在流行病学研究中，已经发现 IBD 患者的 Se 水平较低。几项 IBD 的实验模型表明，Se 或硒蛋白在微炎症中起关键作用。我们在这篇综述中讨论了 Se 与 IBD 之间的关系，重点总结了 Se 在 IBD 中的作用机制和应用。
