Park Eunjin, Lee Nam Ho, Joo Hong-Gu, Jee Youngheun
College of Veterinary Medicine and Applied Radiological Science Research Institute, Cheju National University, Jeju 690-756, South Korea.
Biochem Biophys Res Commun. 2008 Aug 8;372(4):792-7. doi: 10.1016/j.bbrc.2008.05.140. Epub 2008 Jun 2.
To investigate the radioprotective potential of eckol, a component of the seaweed Ecklonia cava, against radiation in vivo, we evaluated the effect of eckol on cyto- and histo-protective capability of the lymphocytes and intestine against damage induced by a single whole body irradiation (WBI) in vivo. Here, we ascertained that eckol protected the lymphocytes' viability and rescued intestinal cells from radiation-induced apoptosis by decreasing the amount of pro-apoptotic p53 and Bax and increasing that of anti-apoptotic Bcl-2. These findings indicate that the overexpression of anti-apoptotic protein, which may lead to resistance to DNA damage, is involved deeply in protection of gastrointestinal cells after irradiation. Thus, eckol that can protect cells and tissues against ionizing radiation may have considerable potential as adjuncts to successful radiotherapy.
为了研究海蕴（Ecklonia cava）的一种成分eckol在体内对辐射的防护潜力，我们评估了eckol对淋巴细胞和肠道在体内单次全身照射（WBI）诱导损伤的细胞保护和组织保护能力的影响。在此，我们确定eckol通过减少促凋亡蛋白p53和Bax的量以及增加抗凋亡蛋白Bcl-2的量，保护了淋巴细胞的活力并使肠道细胞免于辐射诱导的凋亡。这些发现表明，抗凋亡蛋白的过表达可能导致对DNA损伤的抗性，这在照射后对胃肠道细胞的保护中起重要作用。因此，能够保护细胞和组织免受电离辐射的eckol作为成功放疗的辅助剂可能具有相当大的潜力。
