Herukka Sanna-Kaisa, Pennanen Corina, Soininen Hilkka, Pirttilä Tuula
Department of Neurology, University of Kuopio, Kuopio, Finland.
J Alzheimers Dis. 2008 May;14(1):51-7. doi: 10.3233/jad-2008-14105.
Cerebrospinal fluid (CSF) biomarkers and medial temporal lobe (MTL) atrophy predict the progression of mild cognitive impairment (MCI) to Alzheimer's disease (AD). We investigated the association between the CSF biomarkers and MTL atrophy and the ability of these measures to predict AD in MCI patients in the same study population. The study included 21 MCI patients of whom eight progressed to AD during the study. CSF biomarkers were measured by using ELISA method and volumes of MTL structures were assessed by magnetic resonance imaging (MRI). Abeta42 levels were lower and tau and phospho-tau levels were higher in progressive subjects. The progressive subjects had lower volumes in all MRI measures. Tau and phospho-tau correlated inversely with hippocampal volumes and left entorhinal cortex volume in the whole study group. In the stable group, tau correlated with hippocampal volumes. Phospho-tau [corrected] had a negative correlation whereas Abeta42 [corrected] exhibited a positive correlation with left hippocampal volume in the progressive group. These results indicate that both measures may reflect the ongoing neurodegenerative process in the progressive MCI patients. However, the order of the changes in the CSF biomarkers and MTL atrophy remain unclear due to a small number of studied subjects and study design.
脑脊液（CSF）生物标志物和内侧颞叶（MTL）萎缩可预测轻度认知障碍（MCI）向阿尔茨海默病（AD）的进展。在同一研究人群中，我们调查了脑脊液生物标志物与MTL萎缩之间的关联以及这些指标预测MCI患者发生AD的能力。该研究纳入了21例MCI患者，其中8例在研究期间进展为AD。采用酶联免疫吸附测定（ELISA）法检测脑脊液生物标志物，并通过磁共振成像（MRI）评估MTL结构的体积。进展型受试者的β淀粉样蛋白42（Abeta42）水平较低，而tau蛋白和磷酸化tau蛋白水平较高。在所有MRI测量指标中，进展型受试者的体积均较小。在整个研究组中，tau蛋白和磷酸化tau蛋白与海马体积及左侧内嗅皮质体积呈负相关。在稳定组中，tau蛋白与海马体积相关。在进展型组中，磷酸化tau蛋白[校正后]与左侧海马体积呈负相关，而Abeta42[校正后]与左侧海马体积呈正相关。这些结果表明，这两种指标可能反映了进展型MCI患者中正在进行的神经退行性过程。然而，由于研究对象数量较少和研究设计的原因，脑脊液生物标志物和MTL萎缩变化的顺序仍不明确。
