认知功能正常的老年人脑脊液tau蛋白标志物、海马体积与延迟首因效应表现之间的关系。
The relationship between CSF tau markers, hippocampal volume and delayed primacy performance in cognitively intact elderly individuals.
作者信息
Bruno Davide, Grothe Michel J, Nierenberg Jay, Teipel Stefan J, Zetterberg Henrik, Blennow Kaj, Pomara Nunzio
机构信息
Department of Psychology, Liverpool Hope University, Liverpool, UK.
German Center for Neurodegenerative Diseases (DZNE) - Rostock/Greifswald, Rostock, Germany.
出版信息
Alzheimers Dement (Amst). 2015 Mar 1;1(1):81-86. doi: 10.1016/j.dadm.2014.11.002.
BACKGROUND
Primacy performance in recall has been shown to predict cognitive decline in cognitively intact elderly, and conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD). Delayed primacy performance, but not delayed non-primacy performance, has been shown to be associated with hippocampal volume in cognitively intact older individuals. Since presence of neurofibrillary tangles is an early sign of AD-related pathology, we set out to test whether cerebrospinal fluid (CSF) levels of tau had an effect on delayed primacy performance, while controlling for hippocampal volume and CSF Aβ 1-42 levels.
METHODS
Forty-seven individuals, 60 or older and cognitively intact, underwent a multi-session study including lumbar puncture, an MRI scan of the head and memory testing.
RESULTS
Our regression analyses show that CSF levels of hyperphosphorylated (P) tau are only associated with reduced delayed primacy performance when hippocampal volumes are smaller.
CONCLUSION
Our findings suggest that hippocampal size may play a protective role against the negative effects of P tau on memory.
背景
在认知功能正常的老年人中，回忆中的首因效应已被证明可预测认知能力下降以及从轻度认知障碍（MCI）转变为阿尔茨海默病（AD）。在认知功能正常的老年人中，延迟首因效应而非延迟非首因效应已被证明与海马体积有关。由于神经纤维缠结的存在是AD相关病理的早期迹象，我们着手测试脑脊液（CSF）中tau蛋白水平在控制海马体积和CSF Aβ 1-42水平的情况下是否对延迟首因效应有影响。
方法
47名60岁及以上且认知功能正常的个体接受了一项多阶段研究，包括腰椎穿刺、头部MRI扫描和记忆测试。
结果
我们的回归分析表明，只有当海马体积较小时，脑脊液中高磷酸化（P）tau蛋白水平才与延迟首因效应降低有关。
结论
我们的研究结果表明，海马大小可能对P tau蛋白对记忆的负面影响起到保护作用。
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