Matsuda Kazuya, Kobayashi Shintaro, Yamashita Misato, Hirayama Kazuko, Kadosawa Tsuyoshi, Taniyama Hiroyuki
Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
J Vet Med Sci. 2008 May;70(5):479-81. doi: 10.1292/jvms.70.479.
Sarcomatous proliferation of spindle cells was present in the mammary gland and many metastatic sites in a 10-year-old female domestic cat with tubulopapillary carcinoma in the mammary gland. Transition from neoplastic tubular structures to spindle cells in the primary site and fascicular proliferation of the spindle cells with or without coexistance of tubulopapillary carcinoma in the primary and metastatic sites were observed. Most of spindle cells were positive for cytokeratin CAM5.2 as well as the normal luminal epithelium but not the myoepithelium. From these results, this case was diagnosed as tubulopapillary carcinoma with spindle cell metaplasia and it was clarified that neoplastic luminal epithelial cells can transform to sarcomatous appearence.
在一只10岁雌性家猫中，乳腺出现梭形细胞肉瘤样增殖，且在多个转移部位也有出现，该猫乳腺存在小管乳头状癌。观察到在原发部位肿瘤性管状结构向梭形细胞转变，以及原发和转移部位梭形细胞呈束状增殖，伴或不伴有小管乳头状癌共存。大多数梭形细胞细胞角蛋白CAM5.2呈阳性，正常管腔上皮细胞也是如此，但肌上皮细胞呈阴性。根据这些结果，该病例被诊断为伴有梭形细胞化生的小管乳头状癌，并明确肿瘤性管腔上皮细胞可转变为肉瘤样外观。
