Sá E Lemos Eva, Lima de Carvalho Hugo, Gil da Costa Rui M, Pinto da Cunha Nazaré
CEDIVET - Laboratório Clínico Veterinário, Porto, Portugal.
LEPABE - Faculdade de Engenharia da Universidade do Porto, Porto, Portugal.
Vet Clin Pathol. 2018 Mar;47(1):142-145. doi: 10.1111/vcp.12565. Epub 2018 Jan 23.
A 6-year-old female neutered European Shorthair cat was presented with a 2-day history of lethargy and hyporexia. On physical examination, the cat was slightly depressed and had a 2.5 cm nodule in the left 3 mammary gland. The hemogram revealed mild leukocytosis with mature neutrophilia and moderate thrombocytopenia. On blood smear evaluation, rare pleomorphic cells, possibly of epithelial origin, were observed mainly at the feathered edge. The animal died about 12 hours after presentation, and a necropsy was performed. On histopathology, the mammary nodule was diagnosed as a tubulopapillary adenocarcinoma with vascular invasion and widespread metastases. Immunocytochemical tests for cytokeratins (AE1/AE3) confirmed the epithelial phenotype of the neoplastic cells observed on the blood smear. The present report describes a feline mammary carcinoma with widespread metastases and the presence of malignant epithelial cells in the peripheral blood referred to as carcinocythemia. This condition has been previously described in people and dogs. To the author's knowledge, this is the first reported case of feline carcinocythemia. As in other species, the phenomenon was associated with a terminal phase of systemic malignancy.
一只6岁已绝育的欧洲短毛猫前来就诊，有2天的嗜睡和食欲减退病史。体格检查时，该猫略显萎靡，左侧第3乳腺有一个2.5厘米的结节。血常规显示轻度白细胞增多伴成熟中性粒细胞增多和中度血小板减少。在血液涂片评估中，主要在血涂片边缘观察到罕见的多形性细胞，可能起源于上皮。该动物在就诊后约12小时死亡，并进行了尸检。组织病理学检查显示，乳腺结节被诊断为伴有血管侵犯和广泛转移的管状乳头状腺癌。细胞角蛋白（AE1/AE3）免疫细胞化学检测证实了血涂片中观察到的肿瘤细胞的上皮表型。本报告描述了一例伴有广泛转移的猫乳腺癌以及外周血中存在恶性上皮细胞，即癌血症。这种情况先前已在人和狗中描述过。据作者所知，这是首例猫癌血症的报告病例。与其他物种一样，这种现象与全身恶性肿瘤的终末期有关。
