Kamihira Takashi, Yano Koji, Tamada Yoko, Matsumoto Takehiro, Miyazato Masaru, Nagaoka Sinya, Ohata Kazuyuki, Abiru Seigo, Komori Atsumasa, Daikoku Manabu, Yatsuhashi Hiroshi, Ishibashi Hiromi
Department of Gastroenterology, NHO National Nagasaki Medical Center, Omura, Nagasaki.
Nihon Shokakibyo Gakkai Zasshi. 2008 Jun;105(6):841-6.
A 52-year-old man was admitted to our hospital for fever, jaundice, and general malaise. Laboratory data revealed elevated serum liver enzyme levels (AST 2377IU/L, ALT 2756IU/L) and bilirubin (T-Bil 3.7 mg/dl). Blood count showed a marked decrease of platelets (2.0 x 10(4)/microl). Serological and virological analysis showed positive results for HEV IgM and HEV RNA, indicating a diagnosis of acute hepatitis E. The serum ferritin level was also markedly elevated (23200 ng/ml). A diagnosis of virus associated hemophagocytic syndrome (VAHS) was strongly suggested. This is the first report of hepatitis E most likely accompanied by VAHS.
一名52岁男性因发热、黄疸和全身不适入住我院。实验室检查数据显示血清肝酶水平升高（谷草转氨酶2377IU/L，谷丙转氨酶2756IU/L）以及胆红素升高（总胆红素3.7mg/dl）。血常规显示血小板显著减少（2.0×10⁴/微升）。血清学和病毒学分析显示戊型肝炎病毒IgM和戊型肝炎病毒RNA呈阳性，提示急性戊型肝炎诊断。血清铁蛋白水平也显著升高（23200ng/ml）。强烈提示诊断为病毒相关性噬血细胞综合征（VAHS）。这是首例极有可能伴有VAHS的戊型肝炎报告。
