Department of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Department of pathogen biology, Basic College of Medicine, Chongqing Medical University, Chongqing, China.
Front Cell Infect Microbiol. 2023 Mar 7;13:1078870. doi: 10.3389/fcimb.2023.1078870. eCollection 2023.
Hepatitis E virus (HEV) is a common cause of acute hepatitis that threatens human health worldwide. With the popularization of detection technology, the reports of hepatitis E have gradually increased. Here, we present a rare case of co-infection with hepatitis E viruses, and . A 52-year-old man was hospitalized because of fatigue, jaundice, and nausea for more than 2 weeks. Laboratory tests showed elevated bilirubin, aminotransferase (ALT), and aspartate aminotransferase (AST); HEV-IgM was positive, and HEV-RNA could be detected. Moreover, parasites were found in the biliary drainage and the biliary culture, which suggested . The patient was effectively treated with praziquantel, imipenem, and hepatoprotective drugs and his clinical symptoms were relieved after 2 months; total bilirubin decreased to 85.1 μmol/L, ALT decreased to 92.4 U/L, and AST decreased to 102 U/L.
戊型肝炎病毒（HEV）是一种常见的威胁全球人类健康的急性肝炎病原体。随着检测技术的普及，戊型肝炎的报告逐渐增多。本研究报道了 1 例罕见的戊型肝炎病毒和肠道病毒 co-infection 病例。1 名 52 岁男性因乏力、黄疸和恶心超过 2 周而住院。实验室检查显示胆红素、丙氨酸转氨酶（ALT）和天门冬氨酸转氨酶（AST）升高；HEV-IgM 阳性，HEV-RNA 可检测到。此外，胆管引流和胆汁培养中发现了寄生虫，提示胆系感染。该患者经吡喹酮、亚胺培南和保肝药物治疗后病情得到有效控制，2 个月后临床症状缓解；总胆红素降至 85.1 μmol/L，ALT 降至 92.4 U/L，AST 降至 102 U/L。
