Batty G David, Shipley Martin J, Mortensen Laust H, Gale Catharine R, Deary Ian J
MRC Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK.
Eur J Cardiovasc Prev Rehabil. 2008 Jun;15(3):359-61. doi: 10.1097/HJR.0b013e3282f738a6.
Examine the relation between IQ in early adulthood and later coronary heart disease (CHD) mortality, and assess the extent to which established risk factors measured in middle-age might explain this gradient.
Cohort study of 4316 male former Vietnam-era US army personnel with IQ scores (mean age 20.4 years), risk factor data (mean age 38.3 years) and 15 years mortality surveillance.
In age-adjusted analyses, lower IQ scores were associated with an increased rate of CHD mortality (hazard ratio per SD decrease in IQ; 95% confidence interval: 1.34; 1.00, 1.79). Adjustment for later chronic disease (1.22; 0.91, 1.64), behavioural (1.29; 0.95, 1.74) and physiological risk factors (1.19; 0.88, 1.62) led to some attenuation of this gradient. This attenuation was particularly pronounced on adding socioeconomic indices to the multivariable model when the IQ-CHD relation was eliminated (1.05; 0.73, 1.52). A similar pattern of association was apparent when cardiovascular disease was the outcome of interest.
High IQ may lead to educational success, well remunerated and higher prestige employment, and this pathway may confer cardio-protection.
研究成年早期智商与后期冠心病（CHD）死亡率之间的关系，并评估中年时测量的既定风险因素在多大程度上可以解释这种梯度关系。
对4316名曾在越南战争时期服役的美国男性陆军人员进行队列研究，记录其智商分数（平均年龄20.4岁）、风险因素数据（平均年龄38.3岁），并进行15年的死亡率监测。
在年龄调整分析中，较低的智商分数与冠心病死亡率增加相关（智商每降低一个标准差的风险比；95%置信区间：1.34；1.00，1.79）。对后期慢性病（1.22；0.91，1.64）、行为（1.29；0.95，1.74）和生理风险因素（1.19；0.88，1.62）进行调整后，这种梯度关系有所减弱。当在多变量模型中加入社会经济指数且智商与冠心病的关系消除时，这种减弱尤为明显（1.05；0.73，1.52）。当心血管疾病作为研究结果时，也出现了类似的关联模式。
高智商可能导致教育成功、获得高薪和享有较高声望的工作，而这一途径可能具有心脏保护作用。
