Gale Catharine R, Eadie Elizabeth, Thomas Avril, Bastin Mark E, Starr John M, Wardlaw Joanna, Deary Ian J
Centre for Cognitive Ageing & Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom.
Centre for Clinical Brain Sciences, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom; Department of Neuroradiology, Western General Hospital, Edinburgh, United Kingdom.
PLoS One. 2015 Apr 27;10(4):e0125280. doi: 10.1371/journal.pone.0125280. eCollection 2015.
There is some evidence that people who score higher on tests of intelligence in childhood have lower carotid intima-media thickness and higher ankle brachial index in middle age. These findings need replicating in other, older populations. We investigated the prospective relationship between intelligence in childhood and atherosclerosis in the carotid and peripheral arteries at age 73 years.
Participants were 713 members of the Lothian Birth Cohort 1936 whose intelligence was assessed at age 11 years. At age 73 years, carotid intima-media thickness and degree of stenosis were measured using ultrasound imaging; ankle-brachial index was measured using Doppler ultrasound.
There were no significant associations between intelligence at age 11 and measures of atherosclerosis at age 73. In age- and sex-adjusted analyses, for a standard deviation higher score in intelligence, intima-media thickness (x 10) was lower by 0.07 (-0.20, 0.06) mm and ankle brachial index (x 10) was lower by 0.09 (-0.24, 0.07); odds ratios for having carotid stenosis >25% or peripheral arterial disease were 0.98 (0.82, 1.16) and 1.05 (0.81, 1.36) respectively.
In this study of people aged 73 years, higher childhood intelligence was not associated with reduced risk of atherosclerosis in the carotid or peripheral arteries.
有证据表明，童年时期智力测试得分较高的人在中年时颈动脉内膜中层厚度较低，踝臂指数较高。这些发现需要在其他老年人群中进行重复验证。我们调查了73岁时儿童期智力与颈动脉和外周动脉粥样硬化之间的前瞻性关系。
参与者为洛锡安1936年出生队列的713名成员，他们在11岁时接受了智力评估。在73岁时，使用超声成像测量颈动脉内膜中层厚度和狭窄程度；使用多普勒超声测量踝臂指数。
11岁时的智力与73岁时的动脉粥样硬化测量指标之间没有显著关联。在年龄和性别调整分析中，智力得分每高出一个标准差，内膜中层厚度（×10）降低0.07（-0.20，0.06）mm，踝臂指数（×10）降低0.09（-0.24，0.07）；颈动脉狭窄>25%或外周动脉疾病的比值比分别为0.98（0.82，1.16）和1.05（0.81，1.36）。
在这项对73岁人群的研究中，较高的儿童期智力与颈动脉或外周动脉粥样硬化风险降低无关。
