Endocrine Unit, Department of Clinical Physiopathology, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders (DENOThe), University of Florence, 50139 Florence, Italy.
PPAR Res. 2008;2008:917815. doi: 10.1155/2008/917815.
Neuroblastoma (NB) is the most common extracranial tumor in children and accounts for around 15% of all paediatric oncology deaths. The treatment of NB includes surgery, chemotherapy, and radiotherapy. Unfortunately, most children with NB present with advanced disease, and more than 60% of patients with high-risk features will have a poor prognosis despite intensive therapy. Agonists of the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) have been shown to have pleiotropic effects, including antineoplastic effects. The studies that addressed the role and the possible mechanism(s) of action of PPARgamma in NB cells are reviewed.
神经母细胞瘤（NB）是儿童中最常见的颅外肿瘤，约占所有儿科肿瘤死亡人数的 15%。NB 的治疗包括手术、化疗和放疗。不幸的是，大多数 NB 患儿就诊时已处于晚期疾病，尽管进行强化治疗，仍有 60%以上具有高危特征的患者预后不良。核受体过氧化物酶体增殖物激活受体γ（PPARγ）激动剂已显示出多种作用，包括抗肿瘤作用。本文回顾了 PPARγ在 NB 细胞中的作用及其可能的作用机制的研究。
