Opanasopit Praneet, Ruktanonchai Uracha, Suwantong Orawan, Panomsuk Suwannee, Ngawhirunpat Tanasait, Sittisombut Chavalit, Suksamran Tittaya, Supaphol Pitt
Faculty of Pharmacy, Silpakorn University, Thailand.
J Cosmet Sci. 2008 May-Jun;59(3):233-42.
Electrospinning is a process used to produce ultrafine fibers with diameters in the nanometer range. Electrospun fiber mats have high potentials for biomedical uses, due to their high surface area and ease of drug incorporation into the fibers. They can be used as carriers for drug delivery and can enhance drug release and skin permeability. The aim of this study was to prepare electrospun fiber mats and to incorporate extracts from the fruit hull of mangosteen. Antioxidant activity and extract release were determined and compared between the extract incorporated in the electrospun fiber mats and in the cast films. Poly(vinyl alcohol) (PVA) was selected as the polymer matrix. Extracts in the amount of 2.5%, 5%, and 10% w/w, based on the weight of PVA, were incorporated with 10% w/w PVA to finally obtain electrospun fiber mats and cast films. The extract content was evaluated by antioxidative activity using the 2,2-diphenyl-1-picryhydrazyl (DPPH) method. The morphology of the electrospun fiber mats was analyzed using a scanning electron microscope (SEM). The results showed that the diameters of the fibers were in nanoscales and that no crystal of the extract was found at any concentration of the extract. The extract contents in the electrospun fiber mats prepared at 2.5%, 5%, and 10% w/w of the extract were 9.6%, 9.7%, and 10.8% of the initial loading concentration, respectively, whereas, those in the cast films were 23.9%, 14.5%, and 21.0%, respectively. The release of the extract from the electrospun fiber mats prepared at 2.5%, 5%, and 10% w/w of the extract at 120 min were 73.2%, 83.6%, and 81.3% w/w, respectively. However, much slower release from the cast films was observed (i.e., 4.3%, 29.1%, and 40.8% w/w, respectively).
静电纺丝是一种用于生产直径在纳米范围内的超细纤维的工艺。由于静电纺丝纤维垫具有高表面积且易于将药物掺入纤维中，因此在生物医学应用方面具有很高的潜力。它们可用作药物递送的载体，并可增强药物释放和皮肤渗透性。本研究的目的是制备静电纺丝纤维垫并掺入山竹果皮提取物。测定并比较了掺入静电纺丝纤维垫和流延膜中的提取物的抗氧化活性和提取物释放情况。选择聚乙烯醇（PVA）作为聚合物基质。基于PVA的重量，将2.5%、5%和10% w/w的提取物与10% w/w的PVA混合，最终获得静电纺丝纤维垫和流延膜。使用2,2-二苯基-1-苦基肼（DPPH）法通过抗氧化活性评估提取物含量。使用扫描电子显微镜（SEM）分析静电纺丝纤维垫的形态。结果表明，纤维直径处于纳米尺度，且在任何提取物浓度下均未发现提取物晶体。以2.5%、5%和10% w/w的提取物制备的静电纺丝纤维垫中的提取物含量分别为初始负载浓度的9.6%、9.7%和10.8%，而流延膜中的提取物含量分别为23.9%、14.5%和21.0%。以2.5%、5%和10% w/w的提取物制备的静电纺丝纤维垫在120分钟时的提取物释放率分别为73.2%、83.6%和81.3% w/w。然而，观察到流延膜的释放要慢得多（即分别为4.3%、29.1%和40.8% w/w）。
