Department of Chemistry, Wuhan University, Wuhan 430072, China.
Carbohydr Res. 2011 Aug 16;346(11):1337-41. doi: 10.1016/j.carres.2011.04.040. Epub 2011 May 3.
Nano-fibrous mats have been successfully prepared by electrospinning of the blend solutions of cationic cellulose derivatives (PQ-4) and polyvinyl alcohol (PVA). Effects of the blending ratio and applied voltage on the morphology and diameter of the electrospun nano-fibers were investigated. The average diameter of the PQ-4/PVA blend fibers was in the range of 150-250 nm. The electrospinning process became instable and the fiber diameter distribution broadened with increasing PQ-4 content and applied voltage. The antibacterial activity of electrospun PQ-4/PVA blend mats against Gram-negative bacteria Escherichia coli and Gram-positive bacteria Staphylococcus aureus indicated potential for biomedical use.
纳米纤维垫已成功通过阳离子纤维素衍生物（PQ-4）和聚乙烯醇（PVA）共混溶液的静电纺丝制备而成。研究了共混比对电纺纳米纤维形态和直径的影响以及施加电压。PQ-4/PVA 共混纤维的平均直径在 150-250nm 范围内。随着 PQ-4 含量和施加电压的增加，静电纺丝过程变得不稳定，纤维直径分布变宽。电纺 PQ-4/PVA 共混垫对革兰氏阴性菌大肠杆菌和革兰氏阳性菌金黄色葡萄球菌的抗菌活性表明其在生物医学中的应用潜力。
