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Metformin and the intestine.

作者信息

Bailey C J, Wilcock C, Scarpello J H B

出版信息

Diabetologia. 2008 Aug;51(8):1552-3. doi: 10.1007/s00125-008-1053-5. Epub 2008 Jun 5.

DOI:10.1007/s00125-008-1053-5
PMID:18528677
Abstract
摘要

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Metformin and the intestine.二甲双胍与肠道
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2
Metformin causes a futile intestinal-hepatic cycle which increases energy expenditure and slows down development of a type 2 diabetes-like state.二甲双胍引起无效的肠肝循环，增加能量消耗，减缓 2 型糖尿病样状态的发展。
Mol Metab. 2017 May 5;6(7):737-747. doi: 10.1016/j.molmet.2017.05.002. eCollection 2017 Jul.
3
Mechanisms of metformin action in non-insulin-dependent diabetes mellitus.二甲双胍在非胰岛素依赖型糖尿病中的作用机制。
Diabetes Metab Rev. 1995 Sep;11 Suppl 1:S51-6. doi: 10.1002/dmr.5610110508.
4
Metformin: old friend, new ways of action-implication of the gut microbiome?二甲双胍：老朋友，新作用途径——肠道微生物组的影响？
Curr Opin Clin Nutr Metab Care. 2018 Jul;21(4):294-301. doi: 10.1097/MCO.0000000000000468.
5
Metformin acutely lowers blood glucose levels by inhibition of intestinal glucose transport.二甲双胍通过抑制肠道葡萄糖转运来急性降低血糖水平。
Sci Rep. 2019 Apr 16;9(1):6156. doi: 10.1038/s41598-019-42531-0.
6
Diffuse bowel uptake of 18F-FDG on PET/CT examination of a patient with diabetes treated with metformin.一名接受二甲双胍治疗的糖尿病患者在PET/CT检查中出现18F-FDG在肠道的弥漫性摄取。
BMJ Case Rep. 2014 Apr 3;2014:bcr2013202058. doi: 10.1136/bcr-2013-202058.
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The target of metformin in type 2 diabetes.二甲双胍在2型糖尿病中的作用靶点。
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Glucose utilization is suppressed in the gut of insulin-resistant high fat-fed rats and is restored by metformin.在胰岛素抵抗的高脂喂养大鼠的肠道中，葡萄糖利用受到抑制，而二甲双胍可使其恢复。
Biochem Pharmacol. 2006 Dec 15;72(12):1757-62. doi: 10.1016/j.bcp.2006.08.020.
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Enhanced Release of Glucose Into the Intraluminal Space of the Intestine Associated With Metformin Treatment as Revealed by [F]Fluorodeoxyglucose PET-MRI.[F]氟脱氧葡萄糖 PET-MRI 显示，二甲双胍治疗可增强葡萄糖向肠腔内的释放。
Diabetes Care. 2020 Aug;43(8):1796-1802. doi: 10.2337/dc20-0093. Epub 2020 Jun 3.
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Metformin: fifty-two not out.二甲双胍：五十二而不衰。
J Indian Med Assoc. 2009 Nov;107(11):779-84.

引用本文的文献

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Low-dose metformin requires brain Rap1 for its antidiabetic action.低剂量二甲双胍的抗糖尿病作用需要大脑中的Rap1。
Sci Adv. 2025 Aug;11(31):eadu3700. doi: 10.1126/sciadv.adu3700. Epub 2025 Jul 30.
2
An update on current type 2 diabetes mellitus (T2DM) druggable targets and drugs targeting them.2型糖尿病（T2DM）当前可成药靶点及针对这些靶点的药物的最新进展。
Mol Divers. 2025 Mar 13. doi: 10.1007/s11030-025-11149-y.
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The Gut Microbiota-Related Antihyperglycemic Effect of Metformin.二甲双胍与肠道微生物群相关的降血糖作用

本文引用的文献

1
Metformin and its liver targets in the treatment of type 2 diabetes.二甲双胍及其肝脏靶点在2型糖尿病治疗中的作用
Curr Drug Targets Immune Endocr Metabol Disord. 2003 Jun;3(2):151-69. doi: 10.2174/1568008033340298.
2
Metformin.二甲双胍
N Engl J Med. 1996 Feb 29;334(9):574-9. doi: 10.1056/NEJM199602293340906.
3
Accumulation of metformin by tissues of the normal and diabetic mouse.二甲双胍在正常和糖尿病小鼠组织中的蓄积。
Pharmaceuticals (Basel). 2025 Jan 6;18(1):55. doi: 10.3390/ph18010055.
4
Metformin targets mitochondrial complex I to lower blood glucose levels.二甲双胍作用于线粒体复合物I以降低血糖水平。
Sci Adv. 2024 Dec 20;10(51):eads5466. doi: 10.1126/sciadv.ads5466. Epub 2024 Dec 18.
5
Apoptotic and proliferative processes in the small intestine of rats with type 2 diabetes mellitus after metformin and propionic acid treatment.二甲双胍和丙酸治疗后2型糖尿病大鼠小肠中的凋亡和增殖过程
Front Pharmacol. 2024 Oct 16;15:1477793. doi: 10.3389/fphar.2024.1477793. eCollection 2024.
6
Combined Administration of Metformin and Propionate Reduces the Degree of Oxidative/Nitrosative Damage of Hypothalamic Neurons in Rat Model of Type 2 Diabetes Mellitus.二甲双胍与丙酸盐联合给药可减轻2型糖尿病大鼠模型下丘脑神经元的氧化/亚硝化损伤程度。
Mol Neurobiol. 2025 Apr;62(4):4338-4354. doi: 10.1007/s12035-024-04529-2. Epub 2024 Oct 24.
7
Metformin-Associated Gastrointestinal Adverse Events Are Reduced by Probiotics: A Meta-Analysis.益生菌可减少二甲双胍相关的胃肠道不良事件：一项荟萃分析。
Pharmaceuticals (Basel). 2024 Jul 5;17(7):898. doi: 10.3390/ph17070898.
8
Restricting Colorectal Cancer Cell Metabolism with Metformin: An Integrated Transcriptomics Study.用二甲双胍限制结肠直肠癌细胞代谢：一项整合转录组学研究
Cancers (Basel). 2024 May 29;16(11):2055. doi: 10.3390/cancers16112055.
9
Efficacy and Safety of Metformin and Atorvastatin Combination Therapy vs. Monotherapy with Either Drug in Type 2 Diabetes Mellitus and Dyslipidemia Patients (ATOMIC): Double-Blinded Randomized Controlled Trial.二甲双胍和阿托伐他汀联合治疗与单药治疗 2 型糖尿病伴血脂异常患者的疗效和安全性（ATOMIC）：双盲随机对照试验。
Diabetes Metab J. 2024 Jul;48(4):730-739. doi: 10.4093/dmj.2023.0077. Epub 2024 May 20.
10
Metformin-induced changes of the gut microbiota in patients with type 2 diabetes mellitus: results from a prospective cohort study.二甲双胍对 2 型糖尿病患者肠道微生物群的影响：一项前瞻性队列研究的结果。
Endocrine. 2024 Sep;85(3):1178-1192. doi: 10.1007/s12020-024-03828-x. Epub 2024 May 18.
Xenobiotica. 1994 Jan;24(1):49-57. doi: 10.3109/00498259409043220.
4
Importance of the intestine as a site of metformin-stimulated glucose utilization.肠道作为二甲双胍刺激葡萄糖利用部位的重要性。
Br J Pharmacol. 1994 Jun;112(2):671-5. doi: 10.1111/j.1476-5381.1994.tb13128.x.
5
Metformin kinetics in healthy subjects and in patients with diabetes mellitus.健康受试者和糖尿病患者体内二甲双胍的动力学
Br J Clin Pharmacol. 1981 Aug;12(2):235-46. doi: 10.1111/j.1365-2125.1981.tb01206.x.
6
Hypoglycaemic effect of metformin in genetically obese (fa/fa) rats results from an increased utilization of blood glucose by intestine.二甲双胍对遗传性肥胖（fa/fa）大鼠的降血糖作用源于肠道对血糖利用的增加。
Biochem J. 1989 Sep 15;262(3):881-5. doi: 10.1042/bj2620881.
7
Sites of metformin-stimulated glucose metabolism.二甲双胍刺激葡萄糖代谢的部位。
Biochem Pharmacol. 1990 Jun 1;39(11):1831-4. doi: 10.1016/0006-2952(90)90136-9.
8
Reconsideration of inhibitory effect of metformin on intestinal glucose absorption.重新审视二甲双胍对肠道葡萄糖吸收的抑制作用。
J Pharm Pharmacol. 1991 Feb;43(2):120-1. doi: 10.1111/j.2042-7158.1991.tb06645.x.
9
Effect of metformin on glucose metabolism in the splanchnic bed.二甲双胍对内脏床葡萄糖代谢的影响。
Br J Pharmacol. 1992 Apr;105(4):1009-13. doi: 10.1111/j.1476-5381.1992.tb09093.x.