饮食失调男性患者患骨质疏松症的风险高。

High risk of osteoporosis in male patients with eating disorders.

作者信息

Mehler Philip S, Sabel Allison L, Watson Tureka, Andersen Arnold E

机构信息

Department of Internal Medicine, Denver Health Medical Center, Denver, Colorado 80204, USA.

出版信息

Int J Eat Disord. 2008 Nov;41(7):666-72. doi: 10.1002/eat.20554.

DOI:10.1002/eat.20554

PMID:18528874

Abstract

OBJECTIVE

Osteoporosis has traditionally been considered a female problem. This study's purpose is to evaluate bone mineral density (BMD) in males with eating disorders.

METHOD

Charts of 70 consecutive males admitted to an eating disorder program were reviewed. Females admitted during the same time period were used for comparison. BMD was measured by dual-energy X-ray absorptiometry.

RESULTS

Thirty-six percent (19/53) had osteopenia and 26% (14/53) had osteoporosis at the lumbar spine. A disproportionate number of males with anorexia restricting or binge/purge subtype (ANR/ANB) had osteoporosis, as well as those of older age, lower weights, and longer illness duration. BMD for ANR and ANB males was significantly lower than females (p = .02 and p = .03, respectively). In multivariate stepwise linear and logistic regression, lowest BMI and illness duration predicted lumbar Z-scores.

CONCLUSION

Males with ANR/ANB often have severe bone disease, which is worse than females, and is best predicted by a patient's lowest BMI and illness duration.

摘要

目的

传统上，骨质疏松症一直被视为女性问题。本研究旨在评估饮食失调男性的骨密度（BMD）。

方法

回顾了连续收治入饮食失调项目的70名男性的病历。同时期收治的女性用作对照。采用双能X线吸收法测量骨密度。

结果

腰椎部位36%（19/53）的男性存在骨质减少，26%（14/53）的男性患有骨质疏松症。患有节食型或暴饮暴食/清除型厌食症（ANR/ANB）的男性、年龄较大的男性、体重较低的男性以及病程较长的男性中，骨质疏松症患者比例过高。ANR和ANB男性的骨密度显著低于女性（分别为p = 0.02和p = 0.03）。在多变量逐步线性和逻辑回归分析中，最低体重指数和病程可预测腰椎Z评分。