Carter Julie H, Stewart Barbara J, Lyons Karen S, Archbold Patricia G
Department of Neurology, Oregon Health and Science University, Portland, Oregon 97239-3098, USA.
Mov Disord. 2008 Jul 15;23(9):1211-6. doi: 10.1002/mds.21686.
Our objective was to understand the impact of motor and nonmotor symptoms of patients with early and middle stage Parkinson's disease (PD) on their spouses' caregiver strain and depression. A sample of 219 spouse caregivers of PD patients participating in a clinical trial was evaluated for six dimensions of caregiver strain and depression using the Family Care Inventory. Motor and nonmotor (i.e., psychological) clinical symptoms collected from PD patients as part of the clinical trial protocol were used as predictors. Seven hierarchical regression analyses were used to determine the contribution of the motor and nonmotor clinical symptoms in explaining variation in each of the seven caregiver-dependent variables. Clinical symptoms explained 9-16% of the variance in caregiver strain and 10% of depression. Motor symptoms explained 0-6% of the variance and nonmotor psychological symptoms explained 7-13% of the variance in caregiver strain. Comparing our findings with literature that is deemed clinically relevant for patient symptoms that predict caregiver strain, we concluded that PD patient symptoms are important predictors of caregiver strain and depression. Patient nonmotor psychological symptoms have a much greater impact on caregiver strain and depression than patient motor symptoms.
我们的目标是了解早中期帕金森病（PD）患者的运动和非运动症状对其配偶照顾者压力及抑郁的影响。使用家庭照顾量表对参与一项临床试验的219名PD患者的配偶照顾者样本进行了照顾者压力和抑郁六个维度的评估。作为临床试验方案的一部分，从PD患者收集的运动和非运动（即心理）临床症状用作预测指标。使用七次分层回归分析来确定运动和非运动临床症状在解释七个照顾者相关变量各自变化中的作用。临床症状解释了照顾者压力中9 - 16%的方差以及抑郁中10%的方差。运动症状解释了0 - 6%的方差，非运动心理症状解释了照顾者压力中7 - 13%的方差。将我们的研究结果与被认为与预测照顾者压力的患者症状具有临床相关性的文献进行比较，我们得出结论，PD患者症状是照顾者压力和抑郁的重要预测指标。患者的非运动心理症状对照顾者压力和抑郁的影响远大于患者的运动症状。
