区域头颈癌中心的细针穿刺细胞学检查：与系统评价和荟萃分析的比较
Fine-needle aspiration cytology in a regional head and neck cancer center: comparison with a systematic review and meta-analysis.
作者信息
Tandon Sankalap, Shahab Riad, Benton James I, Ghosh Samit K, Sheard Jonathan, Jones Terry M
机构信息
Department of Otolaryngology-Head and Neck Surgery, Aintree University Hospitals NHS Foundation Trust, Lower Lane, Liverpool L97AL, United Kingdom.
出版信息
Head Neck. 2008 Sep;30(9):1246-52. doi: 10.1002/hed.20849.
BACKGROUND
Fine-needle aspiration cytology (FNAC) is used to diagnose masses presenting in the head and neck region. No systematic review of FNAC in this group has yet been performed.
METHODS
A systematic review of the published literature and meta-analysis of data extracted from the included studies were compared with a 10-year review of head and neck FNAC from our institution.
RESULTS
Systematic review identified 30 studies; 3459 FNAC aspirates from all head and neck sites were included. Overall results were as follows: sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) were 89.6%, 96.5%, 93.1%, 96.2%, and 90.3%, respectively. Two thousand seven hundred two head and neck aspirates were included in our institutional review. Sensitivity, specificity, PPV, NPV, and accuracy were 89.5%, 98.5%, 97.3%, 94.0%, and 95.1%, respectively.
CONCLUSION
Meta-analysis and comparative systematic review confirm that FNAC is highly effective in the diagnosis of head and neck masses, with some limitations.
背景
细针穿刺细胞学检查（FNAC）用于诊断头颈部出现的肿块。尚未对该组中的FNAC进行系统评价。
方法
将已发表文献的系统评价和从纳入研究中提取的数据的荟萃分析与我们机构对头颈部FNAC的10年回顾进行比较。
结果
系统评价确定了30项研究；纳入了来自所有头颈部部位的3459份FNAC吸出物。总体结果如下：敏感性、特异性、准确性、阳性预测值（PPV）和阴性预测值（NPV）分别为89.6%、96.5%、93.1%、96.2%和90.3%。我们的机构回顾纳入了2702份头颈部吸出物。敏感性、特异性、PPV、NPV和准确性分别为89.5%、98.5%、97.3%、94.0%和95.1%。
结论
荟萃分析和比较性系统评价证实，FNAC在头颈部肿块的诊断中非常有效，但存在一些局限性。
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