Konturek S J, Konturek J W, Kwiecien N, Obtułowicz W, Oleksy J, Hebzda Z, Amon I
Institute of Physiology, Academy of Medicine, Cracow, Poland.
Scand J Gastroenterol. 1991 Mar;26(3):231-6. doi: 10.3109/00365529109025036.
Ten healthy young male subjects took part in a double-blind, placebo-controlled crossover study to assess the effects of nocloprost on gastric microbleeding and endoscopic mucosal injury induced by the administration of aspirin (2.5 g). In addition, basal and pentagastrin-induced gastric acid and pepsin secretion and salivary and plasma contents of epidermal growth factor (EGF) were measured after placebo plus aspirin or nocloprost plus aspirin treatment in these subjects. Nocloprost (100 micrograms/dose) significantly reduced spontaneous gastric microbleeding and almost completely prevented gastric mucosal injury induced by aspirin. Nocloprost failed to affect basal and pentagastrin-stimulated gastric acid and pepsin secretion but increased significantly the salivary outputs and plasma concentrations of EGF. In conclusion, nocloprost is effective in preventing gastric injury by aspirin even at a non-antisecretory dose, and this protection may involve an excessive release of EGF.
十名健康年轻男性受试者参与了一项双盲、安慰剂对照的交叉研究，以评估诺氯前列素对服用阿司匹林（2.5克）所致胃微出血和内镜下黏膜损伤的影响。此外，在这些受试者接受安慰剂加阿司匹林或诺氯前列素加阿司匹林治疗后，测量了基础胃酸和胃泌素诱导的胃酸及胃蛋白酶分泌，以及唾液和血浆中表皮生长因子（EGF）的含量。诺氯前列素（100微克/剂量）显著减少了自发性胃微出血，并几乎完全预防了阿司匹林所致的胃黏膜损伤。诺氯前列素未能影响基础胃酸和胃泌素刺激的胃酸及胃蛋白酶分泌，但显著增加了EGF的唾液分泌量和血浆浓度。总之，即使在非抗分泌剂量下，诺氯前列素对预防阿司匹林所致胃损伤也有效，且这种保护作用可能涉及EGF的过度释放。
