Konturek S J, Kwiecień N, Obtułowicz W, Hebzda Z, Oleksy J
Institute of Physiology, Academy of Medicine, Cracow, Poland.
Scand J Gastroenterol. 1988 Sep;23(7):861-6. doi: 10.3109/00365528809090774.
Ten healthy young male subjects took part in a double-blind, placebo-controlled, crossover trial to assess the effect of colloidal bismuth subcitrate (De-No) on prostaglandin (PG) E2 generation and mucosal integrity in an aspirin (ASA)-treated stomach. After administration of ASA (2.5 g) plus placebo, a marked reduction in mucosal generation of PGE2 (by about 85%) was observed, and this was accompanied by a significant increase in gastric microbleeding and DNA loss and endoscopic and histologic damage of the mucosa. After the combination of De-Nol (300 mg four times daily) with ASA, mucosal generation of PGE2 showed a reduction similar to that in tests with ASA plus placebo, but gastric microbleeding and mucosal damage were significantly reduced. It is concluded that De-Nol has a protective action on ASA-induced gastric microbleeding and that this protection occurs despite a marked suppression of mucosal production of prostaglandins.
十名健康年轻男性受试者参与了一项双盲、安慰剂对照、交叉试验，以评估次枸橼酸铋（得乐）对阿司匹林（ASA）处理的胃中前列腺素（PG）E2生成及黏膜完整性的影响。给予ASA（2.5克）加安慰剂后，观察到黏膜PGE2生成显著减少（约85%），同时伴有胃微出血和DNA损失显著增加以及黏膜的内镜和组织学损伤。在得乐（每日四次，每次300毫克）与ASA联合使用后，黏膜PGE2生成的减少与ASA加安慰剂试验中的情况相似，但胃微出血和黏膜损伤显著减少。得出结论，得乐对ASA诱导的胃微出血具有保护作用，且尽管黏膜前列腺素生成受到显著抑制，这种保护作用仍然存在。
