Delancey John O L, Kane Low Lisa, Miller Janis M, Patel Divya A, Tumbarello Julie A
Pelvic Floor Research Group, University of Michigan, Ann Arbor, MI, USA.
Am J Obstet Gynecol. 2008 Dec;199(6):610.e1-5. doi: 10.1016/j.ajog.2008.04.001. Epub 2008 Jun 4.
There is growing interest in causal factors for pelvic floor disorders. These conditions include pelvic organ prolapse and urinary and fecal incontinence and are affected by a myriad of factors that increase occurrence of symptomatic disease. Unraveling the complex causal network of genetic factors, birth-induced injury, connective tissue aging, lifestyle and comorbid factors is challenging. We describe a graphical tool to integrate the factors affecting pelvic floor disorders. It plots pelvic floor function in 3 major life phases: (1) development of functional reserve during an individual's growth, (2) variations in the amount of injury and potential recovery that occur during and after vaginal birth, and (3) deterioration that occurs with advancing age. This graphical tool accounts for changes in different phases to be integrated to form a disease model to help assess the overlap of different causal factors.
人们对盆底功能障碍的病因越来越感兴趣。这些病症包括盆腔器官脱垂、尿失禁和大便失禁，并且受到无数会增加症状性疾病发生率的因素影响。梳理遗传因素、分娩所致损伤、结缔组织老化、生活方式和合并症因素等复杂的因果网络具有挑战性。我们描述了一种用于整合影响盆底功能障碍因素的图形工具。它绘制了3个主要生命阶段的盆底功能：（1）个体生长过程中功能储备的发展，（2）阴道分娩期间及产后发生的损伤量变化和潜在恢复情况，以及（3）随着年龄增长而出现的功能衰退。这种图形工具考虑了不同阶段的变化，将其整合以形成一个疾病模型，有助于评估不同因果因素的重叠情况。
