Barbara M, Ronchetti F, Manni V, Monini S
Department of Sensory Organs, Otorhinolaryngologic Unit, II Medical School, "La Sapienza" University, Rome, Italy.
Acta Otorhinolaryngol Ital. 2008 Feb;28(1):34-7.
Vestibular schwannoma may present as a sporadic or genetically-based multi-localized benign neoplasm of the internal auditory canal and/or cerebello-pontine angle region. Multiple localization is generally regarded as genetic in origin and often affects the stato-acoustic bundle on both sides. A case of double vestibular schwannoma localized on the same stato-acoustic bundle is presented. After removal, slight histological differences were found between the two separate masses. From these findings, the possibility of a unilateral multiple localization of a vestibular schwannoma is considered plausible within the range of clinical presentation, with negative genetic features. Whether these individual masses might have an autonomous origin or a different growth pattern remains to be fully elucidated.
前庭神经鞘瘤可能表现为内耳道和/或桥小脑角区域的散发性或基于遗传的多灶性良性肿瘤。多灶性通常被认为起源于遗传，且常双侧累及听神经束。本文报告一例双侧前庭神经鞘瘤位于同一听神经束的病例。切除后，发现两个独立肿块之间存在轻微的组织学差异。基于这些发现，在前庭神经鞘瘤临床表现范围内，具有阴性遗传特征的单侧多灶性发生被认为是合理的。这些单个肿块是否可能有自主起源或不同的生长模式仍有待充分阐明。
