含N3O部分新型卟啉的高效通用合成：用于模拟细胞色素c氧化酶的配体

Efficient and versatile synthesis of new porphyrins bearing an N3O moiety: ligands for mimicking cytochrome c oxidase.

作者信息

Ruzié Christian, Even-Hernandez Pascale, Boitrel Bernard

机构信息

Université de Rennes1, Sciences Chimiques de Rennes, Ingénierie Chimique et Molécules du Vivant, UMR CNRS 6226, 35042 Rennes Cedex, France.

出版信息

Org Lett. 2008 Jul 3;10(13):2673-6. doi: 10.1021/ol800731t. Epub 2008 Jun 6.

DOI:10.1021/ol800731t

PMID:18533673

Abstract

Two new generations of ligands for cytochrome c oxidase mimicking have been designed and synthesized via an efficient, convergent, and versatile synthesis. These porphyrins are functionalized with both an internal nitrogen base on one side and a triaza (N3) or a triaza-phenol (N3O) moiety on the other side, attached to the macrocycle by various spacers. Unlike tailed porphyrins, the triaza motif as well as the nitrogen base are linked by two points.

摘要

通过一种高效、收敛且通用的合成方法，设计并合成了两代新型细胞色素c氧化酶模拟配体。这些卟啉在一侧用内部氮碱官能化，在另一侧用三氮杂（N3）或三氮杂酚（N3O）部分官能化，并通过各种间隔基连接到大环上。与带尾卟啉不同，三氮杂基序以及氮碱通过两个点相连。