Vavilova T P, Tolmacheva I I
Stomatologiia (Mosk). 1991 Mar-Apr(2):4-6.
Activities of cysteine and trypsin-like proteinase inhibitors and of cathepsin D were measured in mixed saliva of periodontitis patients with conditions of varying severity. Salivary proteinase inhibitor activities were found related, to a certain measure, to the severity of inflammation. Salivary antitryptic activity was somewhat reduced and cysteine proteinase inhibitor activity elevated in patients with non-severe periodontitis. In cases with medium-severe and severe periodontitis salivary proteinase activity was augmenting, approaching the normal value, whereas cysteine proteinase inhibitor level was significantly decreased. A reduction of salivary inhibitor activity was related to the formation of inhibitor-proteinase complexes, whereas a rise of this activity was explained by release of inhibitors from these complexes resulting from dissociation. This is possibly due to the formation of partially cleaved inhibitor form because of cathepsin effects.
在患有不同严重程度牙周炎的患者的混合唾液中，检测了半胱氨酸和类胰蛋白酶抑制剂以及组织蛋白酶D的活性。发现唾液蛋白酶抑制剂活性在一定程度上与炎症的严重程度相关。在非重度牙周炎患者中，唾液抗胰蛋白酶活性略有降低，半胱氨酸蛋白酶抑制剂活性升高。在中度重度和重度牙周炎病例中，唾液蛋白酶活性增强，接近正常值，而半胱氨酸蛋白酶抑制剂水平显著降低。唾液抑制剂活性的降低与抑制剂 - 蛋白酶复合物的形成有关，而这种活性的升高是由于复合物解离导致抑制剂释放所致。这可能是由于组织蛋白酶的作用形成了部分裂解的抑制剂形式。
