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肿瘤相关性半骨盆切除术后的功能结局和生活质量

Functional outcomes and quality of life after tumor-related hemipelvectomy.

作者信息

Beck Lisa A, Einertson Marlene J, Winemiller Mark H, DePompolo Robert W, Hoppe Kurtis M, Sim Franklin F

机构信息

College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.

出版信息

Phys Ther. 2008 Aug;88(8):916-27. doi: 10.2522/ptj.20070184. Epub 2008 Jun 5.

Abstract

BACKGROUND AND PURPOSE

Hemipelvectomy is a life-changing treatment for pelvic malignancies. This study compared functional outcomes and quality of life of patients following internal or external hemipelvectomies.

SUBJECTS

Ninety-seven patients who underwent tumor-related internal (n=39) or external (n=58) hemipelvectomy surgery between January 1, 1988, and December 31, 2004, participated in the study.

METHODS

Using a descriptive retrospective cohort study design, functional status was evaluated with the Barthel Index at 3 time points. Quality-of-life parameters were evaluated at follow-up using the Linear Analog Self-Assessment tool (LASA).

RESULTS

Data were collected on all 97 patients at rehabilitation consultation and hospital discharge. Follow-up data were obtained via survey on 44% of the original group at a median of 5.8 years (interquartile range [IRQ]=1.7-10.4) after surgery. Median total Barthel Index scores were similar between the internal and external hemipelvectomy groups at the initial physical medicine and rehabilitation assessment (10 [IQR=10-15] versus 10 [IQR=3.75-15]), at discharge (40 [IQR=30-65] versus 50 [IQR=35-66.25]), and at follow-up (92.5 [IQR=76.25-100] versus 92.5 [IQR=78.75-96.25]). Participants with external hemipelvectomies were less independent in bladder function and experienced greater pain severity at follow-up compared with those with internal hemipelvectomies. Overall quality-of-life parameters were similar between the groups.

DISCUSSION AND CONCLUSION

Despite significant differences in surgical procedures, immediate and long-term functional outcomes and quality-of-life parameters were similar among participants with internal and external hemipelvectomies.

摘要

背景与目的

半骨盆切除术是一种改变骨盆恶性肿瘤患者生活的治疗方法。本研究比较了接受内半骨盆切除术或外半骨盆切除术患者的功能结局和生活质量。

研究对象

1988年1月1日至2004年12月31日期间接受与肿瘤相关的内半骨盆切除术(n = 39)或外半骨盆切除术(n = 58)的97例患者参与了本研究。

方法

采用描述性回顾性队列研究设计,在3个时间点使用巴氏指数评估功能状态。随访时使用线性模拟自评工具(LASA)评估生活质量参数。

结果

在康复咨询和出院时收集了所有97例患者的数据。通过调查在手术后中位时间5.8年(四分位间距[IRQ]=1.7 - 10.4)时获得了原研究组44%患者的随访数据。在内半骨盆切除术组和外半骨盆切除术组中,最初的物理医学与康复评估时(10[IQR = 10 - 15]对10[IQR = 3.75 - 15])、出院时(40[IQR = 30 - 65]对50[IQR = 35 - 66.25])以及随访时(92.5[IQR = 76.25 - 100]对92.5[IQR = 78.75 - 96.25]),巴氏指数总分中位数相似。与内半骨盆切除术患者相比,外半骨盆切除术患者在随访时膀胱功能独立性较差且疼痛程度更严重。两组之间总体生活质量参数相似。

讨论与结论

尽管手术方式存在显著差异,但内半骨盆切除术和外半骨盆切除术患者的近期和长期功能结局以及生活质量参数相似。

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