de Rooij Sophia E J A, Govers Annerike C, Korevaar Johanna C, Giesbers Arja W, Levi Marcel, de Jonge Evert
Department of Internal Medicine and Geriatrics, Academic Medical Center, Amsterdam, The Netherlands.
J Am Geriatr Soc. 2008 May;56(5):816-22. doi: 10.1111/j.1532-5415.2008.01671.x. Epub 2008 Apr 1.
To investigate long-term cognitive, functional, and quality-of-life outcomes in very elderly survivors at least 1 year after planned or unplanned surgery or medical intensive care treatment.
Retrospective cohort study.
General, 1,024-bed, tertiary university teaching hospital in The Netherlands.
Two hundred four survivors of a cohort of 578 patients admitted to the medical-surgical intensive care unit (ICU) between January 1997 and December 2002 and alive in December 2003. The majority of survivors underwent elective surgery.
From December 2003 until February 2004, data were collected from 190 patients and 169 relatives. The measures were: Informant Questionnaire on Cognitive Decline short form (IQCODE-SF) (cognition), modified Katz index of activities of daily living (ADLs) (functional status), and EuroQol (EQ-5D) (health-related quality of life). The patients themselves completed the modified Katz ADL index and EQ-5D forms; their caregivers completed the ADL caregiver version and IQCODE-SF.
The mean age at admission+/-standard deviation was 81.7+/-2.4, and the median time after discharge was 3.7 years (range 1-5.9 years). Of the ICU patients who had planned surgery, 57% survived, compared with 11% of the unplanned surgical admissions and 10% of the medical patients. Three-quarters (74.3%) of the patients who lived at home before ICU admission remained at home at follow-up. Eighty-three percent had no severe cognitive impairment, and 76% had no severe physical limitations (33% had moderate, 40% had mild, and 3% had no limitations). The perceived quality of life was similar to that of an age-matched general population.
Long-term survivors of ICU treatment received at the age of 80 and older showed fair-to-good cognitive and physical functioning and quality of life, although few patients who underwent unplanned surgery or who were admitted to the ICU for medical reasons survived.
调查计划内或计划外手术或医疗重症监护治疗后至少1年的高龄幸存者的长期认知、功能和生活质量结局。
回顾性队列研究。
荷兰一所拥有1024张床位的大型三级大学教学医院。
1997年1月至2002年12月期间入住内科-外科重症监护病房(ICU)且在2003年12月仍存活的578例患者中的204例幸存者。大多数幸存者接受了择期手术。
2003年12月至2004年2月期间,从190例患者和169名亲属处收集数据。测量指标包括:简易认知功能下降知情者问卷(IQCODE-SF)(认知功能)、改良的日常生活活动能力Katz指数(ADL)(功能状态)和欧洲五维度健康量表(EQ-5D)(健康相关生活质量)。患者本人填写改良的Katz ADL指数和EQ-5D表格;其照顾者填写ADL照顾者版本和IQCODE-SF。
入院时的平均年龄±标准差为81.7±2.4岁,出院后的中位时间为3.7年(范围1-5.9年)。计划内手术的ICU患者中,57%存活,而计划外手术入院患者的存活率为11%,内科患者的存活率为10%。ICU入院前在家居住的患者中,四分之三(74.3%)在随访时仍在家中。83%的患者无严重认知障碍,76%的患者无严重身体限制(33%有中度限制,40%有轻度限制,3%无限制)。感知生活质量与年龄匹配的普通人群相似。
80岁及以上接受ICU治疗的长期幸存者显示出良好到中等的认知和身体功能以及生活质量,尽管接受计划外手术或因内科原因入住ICU的患者存活者很少。