Kochetov Alex V
Institute of Cytology and Genetics, Novosibirsk, Russia.
Bioessays. 2008 Jul;30(7):683-91. doi: 10.1002/bies.20771.
It is widely suggested that a eukaryotic mRNA typically contains one translation start site and encodes a single functional protein product. However, according to current points of view on translation initiation mechanisms, eukaryotic ribosomes can recognize several alternative translation start sites and the number of experimentally verified examples of alternative translation is growing rapidly. Also, the frequent occurrence of alternative translation events and their functional significance are supported by the results of computational evaluations. The functional role of alternative translation and its contribution to eukaryotic proteome complexity are discussed.
人们普遍认为，真核生物的信使核糖核酸（mRNA）通常包含一个翻译起始位点，并编码一种单一的功能性蛋白质产物。然而，根据目前对翻译起始机制的观点，真核生物核糖体能够识别多个可供选择的翻译起始位点，并且经实验验证的可变翻译实例数量正在迅速增加。此外，计算评估结果也支持了可变翻译事件的频繁发生及其功能意义。本文讨论了可变翻译的功能作用及其对真核生物蛋白质组复杂性的贡献。
